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Anti-CCL3L1 Antibody (CAB2852)

SKU:
CAB2852
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
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Description

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Antibody Name:Anti-CCL3L1 Antibody
Antibody SKU:CAB2852
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 24-93 of human CCL3L1 (NP_066286.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:B cells
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 24-93 of human CCL3L1 (NP_066286.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:APLA ADTP TACC FSYT SRQI PQNF IADY FETS SQCS KPSV IFLT KRGR QVCA DPSE EWVQ KYVS DLEL SA
Gene ID:6349
Uniprot:P16619
Cellular Location:Secreted
Calculated MW:10kDa
Observed MW:12kDa
Synonyms:CCL3L1, 464.2, D17S1718, G0S19-2, LD78, LD78-beta(1-70), LD78BETA, MIP1AP, SCYA3L, SCYA3L1
Background:This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility. This record represents one of two copies that are present on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly. Alternative splicing of this gene results in multiple transcript variants.
UniProt Protein Function:CCL3L1: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1- infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine

Chromosomal Location of Human Ortholog: 17q21.1

Cellular Component: extracellular space; extracellular region

Molecular Function:chemokine activity

Biological Process: negative regulation of cell proliferation; immune response; inflammatory response

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To

NCBI Summary:This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014]
UniProt Code:P16619
NCBI GenInfo Identifier:127077
NCBI Gene ID:414062
NCBI Accession:P16619.1
UniProt Secondary Accession:P16619,Q3B7A8, Q53YA5, Q96I68, A6NGK6, B2RUX4,
UniProt Related Accession:P16619
Molecular Weight:93
NCBI Full Name:C-C motif chemokine 3-like 1
NCBI Synonym Full Names:chemokine (C-C motif) ligand 3-like 3
NCBI Official Symbol:CCL3L3  
NCBI Official Synonym Symbols:LD78; 464.2; SCYA3L; G0S19-2; SCYA3L1; D17S1718; LD78BETA  
NCBI Protein Information:C-C motif chemokine 3-like 1; LD78-beta(1-70); small inducible cytokine A3-like 1; G0/G1 switch regulatory protein 19-2; tonsillar lymphocyte LD78 beta protein; chemokine (C-C motif) ligand 3-like, centromeric
UniProt Protein Name:C-C motif chemokine 3-like 1
UniProt Synonym Protein Names:G0/G1 switch regulatory protein 19-2; LD78-beta(1-70); PAT 464.2; Small-inducible cytokine A3-like 1; Tonsillar lymphocyte LD78 beta proteinCleaved into the following 2 chains:LD78-beta(3-70); LD78-beta(5-70)
Protein Family:C-C motif chemokine
UniProt Gene Name:CCL3L1  
UniProt Entry Name:CL3L1_HUMAN
Anti-CCL3L1 Antibody (CAB2852)Western blot analysis of extracts of B-cell cells, using CCL3L1 antibody (CAB2852) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s.

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