Description
| Product Name: | CD116 monoclonal antibody |
| Product Code: | AGIM0002 |
| Size: | 100 µg in 100 µL |
| Reactivity: | Human |
| Clone: | 4H1 |
| Applications: | Flow Cytometry |
| Conjugate: | Unconjugated |
| Isotype: | IgG1,k |
| Host Species: | Mouse |
| Storage: | Store at -20°C. |
| Uniprot: | P15509 |
| UniProt Protein Function: | CSF2RA: Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4). A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Belongs to the type I cytokine receptor family. Type 5 subfamily. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: Xp22.32 and Yp11.3 Cellular Component: extracellular region; integral to plasma membrane; intracellular; plasma membrane Molecular Function:granulocyte colony-stimulating factor binding; granulocyte colony-stimulating factor receptor activity; protein binding; receptor activity Biological Process: activation of MAPKK activity; axon guidance; cellular protein metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; Ras protein signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway Disease: Surfactant Metabolism Dysfunction, Pulmonary, 4 |
| NCBI Summary: | The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P15509 |
| NCBI GenInfo Identifier: | 121509 |
| NCBI Gene ID: | 1438 |
| NCBI Accession: | P15509.1 |
| UniProt Secondary Accession: | P15509,O00207, Q14429, Q14430, Q14431, Q16564, A7J003 A8KAM1, B4DW68, J3JS76, J3JS77, |
| UniProt Related Accession: | P15509 |
| Molecular Weight: | 31,101 Da |
| NCBI Full Name: | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha |
| NCBI Synonym Full Names: | colony stimulating factor 2 receptor alpha subunit |
| NCBI Official Symbol: | CSF2RAÂ Â |
| NCBI Official Synonym Symbols: | GMR; CD116; CSF2R; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; GM-CSF-R-alpha  |
| NCBI Protein Information: | granulocyte-macrophage colony-stimulating factor receptor subunit alpha |
| UniProt Protein Name: | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha |
| UniProt Synonym Protein Names: | CDw116; CD_antigen: CD116 |
| Protein Family: | Granulocyte-macrophage colony-stimulating factor receptor |
| UniProt Gene Name: | CSF2RAÂ Â |
| UniProt Entry Name: | CSF2R_HUMAN |
