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CD162 monoclonal antibody (AGIM0090)

SKU:
AGIM0090
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
TC2
Conjugation:
Unconjugated
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD162 monoclonal antibody
Product Code:AGIM0090
Size:100 µg in 100 µL
Reactivity:Human
Clone:TC2
Applications:Flow Cytometry
Conjugate:Unconjugated
Isotype:IgG1
Host Species:Mouse
Storage:Store at -20°C. Avoid freeze/thaw cycles. Should be handled under aseptic conditions.
Uniprot:P20062
Background:CD162 (P-selectin glycoprotein ligand-1, PSGL-1) is a sialomucin constitutively expressed as a disulfide-linked homodimer of two 120 kDa subunits on the surface of circulating leukocytes. CD162 serves as a ligand for P- E- and L-selectin, with the highest affinity for P-selectin. It is thus involved in leukocyte rolling at the endothelial surfaces, prerequisite for firm leukocyte adhesion and subsequent transendothelial migration. CD162 also mediates leukocyte-platelet adhesion and interleukocyte contacts. Whereas serving as an adhession molecule on mature leukocytes, CD162 is a potent negative regulator of human hematopoietic progenitors.
UniProt Protein Function:TCN2: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency). This results in various forms of anemia. Belongs to the eukaryotic cobalamin transport proteins family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: lysosomal lumen; extracellular space; extracellular region; endosome

Molecular Function:metal ion binding; cobalamin binding

Biological Process: vitamin metabolic process; cobalamin metabolic process; cobalamin transport; cobalt ion transport; water-soluble vitamin metabolic process

Disease: Transcobalamin Ii Deficiency

NCBI Summary:This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Code:P20062
NCBI GenInfo Identifier:224471876
NCBI Gene ID:6948
NCBI Accession:P20062.3
UniProt Secondary Accession:P20062,Q96FD4, Q9BVI8, Q9UCI5, Q9UCI6, Q9UDM0,
UniProt Related Accession:P20062,AAB25526
Molecular Weight:Calculated MW: 44kDa/47kDaObserved MW: 54kDa
NCBI Full Name:Transcobalamin-2
NCBI Synonym Full Names:transcobalamin II
NCBI Official Symbol:TCN2  
NCBI Official Synonym Symbols:II; TC; TC2; TC-2; TCII; TC II; D22S676; D22S750  
NCBI Protein Information:transcobalamin-2; macrocytic anemia; vitamin B12-binding protein 2; transcobalamin II; macrocytic anemia
UniProt Protein Name:Transcobalamin-2
UniProt Synonym Protein Names:Transcobalamin II; TC II; TCII
Protein Family:Transcobalamin
UniProt Gene Name:TCN2  
UniProt Entry Name:TCO2_HUMAN

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