Description
system_update_altDatasheet
| Product Name: | CD2 monoclonal antibody (Biotin) |
| Product Code: | AGIM0024 |
| Size: | 50 µg in 100 µL |
| Reactivity: | Human |
| Clone: | MEM-65 |
| Applications: | Flow Cytometry |
| Conjugate: | Biotin |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles. |
| Uniprot: | P06729Â |
| Background: | CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Morover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cellcell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. |
