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CD37 monoclonal antibody (PE) (AGIM0356)

SKU:
AGIM0356
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
HH1
Conjugation:
PE
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD37 monoclonal antibody (PE)
Product Code:AGIM0356
Size:100 µL
Reactivity:Human
Clone:HH1
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Do not freeze. Avoid prolonged exposure to light. .
Uniprot:Q8IZA3
Background:CD37, also known as TSPAN26, is a 40 - 45 kDa palmitoylated tetraspanin superfamily glycoprotein that is expressed by lymphocytes and myeloid cells. CD37 directly associates with dectin-1 on macrophages and stabilizes cell surface dectin-1 expression. It also inhibits T cell activation and proliferation by limiting T cell receptor signaling. Human CD37 shares 80% amino acid sequence identity with mouse and rat CD37.
UniProt Protein Function:H1FOO: May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling. Belongs to the histone H1/H5 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding Chromosomal Location of Human Ortholog: 3q22.1 Cellular Component: nucleolus; nucleus Molecular Function: nucleosomal DNA binding Biological Process: nucleosome positioning
UniProt Protein Details:
NCBI Summary:Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The related mouse gene is expressed only in oocytes. [provided by RefSeq, Oct 2015]
UniProt Code:Q8IZA3
NCBI GenInfo Identifier:74762503
NCBI Gene ID:132243
NCBI Accession:Q8IZA3.1
UniProt Secondary Accession:Q8IZA3,Q86WT7
UniProt Related Accession:Q8IZA3
Molecular Weight:21,010 Da
NCBI Full Name:Histone H1oo
NCBI Synonym Full Names:H1 histone family member O, oocyte specific
NCBI Official Symbol:H1FOO  
NCBI Official Synonym Symbols:H1.8; H1oo; osH1  
NCBI Protein Information:histone H1oo
UniProt Protein Name:Histone H1oo
UniProt Synonym Protein Names:Oocyte-specific histone H1; Oocyte-specific linker histone H1; osH1
Protein Family:Histone
UniProt Gene Name:H1FOO  
UniProt Entry Name:H1FOO_HUMAN

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