Anti-CD97 Antibody (CAB3780)
- SKU:
- CAB3780
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-CD97 Antibody |
| Antibody SKU: | CAB3780 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-435 of human CD97 (NP_001775.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:200 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Jurkat, Mouse lung, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-435 of human CD97 (NP_001775.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NLED IMRI LAKS LPKG PFTY ISPS NTEL TLMI QERG DKNV TMGQ SSAR MKLN WAVA AGAE DPGP AVAG ILSI QNMT TLLA NASL NLHS KKQA ELEE IYES SIRG VQLR RLSA VNSI FLSH NNTK ELNS PILF AFSH LESS DGEA GRDP PAKD VMPG PRQE LLCA FWKS DSDR GGHW ATEG CQVL GSKN GSTT CQCS |
| Gene ID: | 976 |
| Uniprot: | P48960 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein, Secreted, extracellular space |
| Calculated MW: | 81kDa/86kDa/91kDa |
| Observed MW: | 105kDa |
| Synonyms: | ADGRE5, CD97, TM7LN1 |
| Background: | This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. |
| UniProt Protein Function: | CD97: Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GPCR, family 2; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 19p13.12 Cellular Component: focal adhesion; integral to plasma membrane; membrane; plasma membrane Molecular Function:protein binding; transmembrane receptor activity Biological Process: cell motility; cell-cell signaling; immune response; inflammatory response |
| NCBI Summary: | This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011] |
| UniProt Code: | P48960 |
| NCBI GenInfo Identifier: | 90110013 |
| NCBI Gene ID: | 976 |
| NCBI Accession: | P48960.4 |
| UniProt Secondary Accession: | P48960,O00718, O76101, Q8NG72, Q8TBQ7, A8K7Z4, B2RBJ9 |
| UniProt Related Accession: | P48960 |
| Molecular Weight: | 86,628 Da |
| NCBI Full Name: | CD97 antigen |
| NCBI Synonym Full Names: | adhesion G protein-coupled receptor E5 |
| NCBI Official Symbol: | ADGRE5Â Â |
| NCBI Official Synonym Symbols: | CD97; TM7LN1Â Â |
| NCBI Protein Information: | CD97 antigen |
| UniProt Protein Name: | CD97 antigen |
| UniProt Synonym Protein Names: | Leukocyte antigen CD97; CD_antigen: CD97 |
| Protein Family: | CD97 antigen |
| UniProt Gene Name: | CD97Â Â |
| UniProt Entry Name: | CD97_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CD97 antibody (CAB3780) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse brain using CD97 antibody (CAB3780) at dilution of 1:100 (40x lens). |
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