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CDKN1B/p27KIP1 Rabbit Polyclonal Antibody (CAB16722)

SKU:
CAB16722
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle
  • Cell Cycle Antibodies 1 Anti-CDKN1B/p27KIP1 Antibody CAB16722
  • Cell Cycle Antibodies 1 Anti-CDKN1B/p27KIP1 Antibody CAB16722
  • Cell Cycle Antibodies 1 Anti-CDKN1B/p27KIP1 Antibody CAB16722
  • Cell Cycle Antibodies 1 Anti-CDKN1B/p27KIP1 Antibody CAB16722
  • Cell Cycle Antibodies 1 Anti-CDKN1B/p27KIP1 Antibody CAB16722
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:CDKN1B/p27KIP1 Rabbit Polyclonal Antibody
SKU:CAB16722
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human CDKN1B/p27KIP1 (NP_004055.1).
Sequence:MSNV RVSN GSPS LERM DARQ AEHP KPSA CRNL FGPV DHEE LTRD LEKH CRDM EEAS QRKW NFDF QNHK PLEG KYEW QEVE KGSL PEFY YRPP RPPK GACK VPAQ ESQD VSGS RPAA PLIG APAN SEDT HLVD PKTD PSDS QTGL AEQC AGIR KRPA TDDS STQN KRAN RTEE NVSD GSPN AGSV EQTP KKPG LRRR QT
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:KIP1; MEN4; CDKN4; MEN1B; P27KIP1; CDKN1B/p27KIP1
Positive Sample:MCF7,293T,HeLa,HepG2,mouse lung,C6,rat lung
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Endosome, Nucleus.
Calculated MW:22kDa
Observed MW:27kDa

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).

Purification Method:Affinity purification
Gene ID:1027
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using CDKN1B/p27KIP1 Rabbit pAb (CAB16722) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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