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Cell Cycle Antibodies 2 Anti-CDKN1C/p57 Kip2 Antibody CAB6843
Key Features

CDKN1C/p57 Kip2 Rabbit Monoclonal Antibody (CAB6843)

Datasheet MSDS
SKU CAB6843
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human
Host Species Rabbit
Synonyms BWS, WBS, p57, BWCR, KIP2, p57Kip2, CDKN1C/p57 Kip2
Research Use Cell Cycle
$173 - $603

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Description

system_update_altDatasheetsystem_update_altMSDS

CDKN1C/p57 Kip2 Monoclonal Antibody (CAB6843)

The CDKN1C/p57 Kip2 Monoclonal Antibody (CAB6843) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is specifically designed for use in various research applications, including immunohistochemistry, immunofluorescence, and Western blot.CDKN1C, also known as p57 Kip2, is a cyclin-dependent kinase inhibitor that functions as a tumor suppressor by halting cell cycle progression. Dysregulation of CDKN1C has been implicated in various cancers, making it a promising target for therapeutic interventions.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:CDKN1C/p57 Kip2 Monoclonal Antibody
SKU:CAB6843
Size:20μL, 100μL
Reactivity:Human
Clone Number:ARC1424
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:MSDA SLRS TSTM ERLV ARGT FPVL VRTS ACRS LFGP VDHE ELSR ELQA RLAE LNAE DQNR WDYD FQQD MPLR GPGR LQWT EVDS DSVP AFYR ETVQ VGRC
Tested Applications:WB ELISA
Recommended Dilution:
WB1:2000 - 1:8000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:BWS, WBS, p57, BWCR, KIP2, p57Kip2, CDKN1C/p57 Kip2
Positive Sample:HeLa treated with Dexamethasone
Cellular Localization:Nucleus.
Calculated MW:32kDa
Observed MW:57kDa

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.

Purification MethodAffinity purification
Gene ID1028
RRIDAB_2863542
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from HeLa cells using CDKN1C/p57 Kip2 Rabbit mAb (CAB6843) at 1:2000 dilution incubated overnight at 4℃. HeLa cells were treated with Dexamethasone (500 nM) at 37℃ for 16hrs . Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3 % nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
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