CENP-A Antibody [5A7-2E11] is a mouse monoclonal antibody directed against CENP-A, offered by Assay Genie for research applications. Reported applications include WB and ICC/IF. Reported reactivity: Human. Supplied as IgG1, purified by Protein G.
CENPA is a histone H3 variant that defines centromeric chromatin and is essential for kinetochore assembly and chromosome segregation. It replaces canonical H3 in centromeric nucleosomes and recruits key centromere proteins such as CENP-C. While primarily studied in mitotic cells, emerging research suggests that CENPA may also play roles in post-mitotic neurons by maintaining chromatin architecture and genome stability. Disruption of centromeric integrity and epigenetic regulation has been linked to neuronal aging and neurodegenerative diseases. CENPA’s role in chromatin dynamics and nuclear organization positions it as a potential biomarker for genomic instability in neurodegeneration. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
CENP-A Antibody [5A7-2E11]
Product SKU:
STMA00057
Size:
100 µg
Target:
CENP-A
Host Species:
Mouse
Antibody Type:
Monoclonal
Clone ID:
5A7-2E11
Research Areas:
Cell Signaling, Epigenetics and Nuclear Signaling
Buffer:
PBS, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, ICC/IF
Antibody Isotype:
IgG1
Purification:
Protein G Purified
Concentration:
1 mg/ml
Reactivity:
Human
Recommended Dilution:
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~18kDa. Recognizes Human CENP-A.
Guarantee:
12 months from date of dispatch
Immunogen:
Synthetic peptide corresponding to a portion of human CENP-A
Immunogen Species:
Human
Accession Number:
NP_001035891.1
Gene ID:
1902-11-23 00:00:00
Swiss-Prot:
P49450
Cellular Localization:
Nucleus | Chromosome | Centromere | Kinetochore
Alternative Names:
CENPA, CENP-A, Centromere autoantigen A, Histone H3-like centromeric protein A
References:
1. Rieder C.L., et al. (1998) Trends Cell Biol. 8: 310-318. 2. Choo K.H. (2000) Trends Cell Biol. 10: 182-188. 3. Muro Y., et al. (2000) Clin. Exp. Immunol. 120: 218-223. 4. Howman E.V., et al. (2000) Proc. Natl. Acad. Sci. USA 97: 1148-1153.
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