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Anti-CFTR Antibody (CAB8386)

SKU:
CAB8386
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Virus
Host Species:
Rabbit
Isotype:
IgG
€139 - €419
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Description

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Antibody Name:Anti-CFTR Antibody
Antibody SKU:CAB8386
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1161-1480 of human CFTR (NP_000483.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HL-60
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1161-1480 of human CFTR (NP_000483.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SRVF KFID MPTE GKPT KSTK PYKN GQLS KVMI IENS HVKK DDIW PSGG QMTV KDLT AKYT EGGN AILE NISF SISP GQRV GLLG RTGS GKST LLSA FLRL LNTE GEIQ IDGV SWDS ITLQ QWRK AFGV IPQK VFIF SGTF RKNL DPYE QWSD QEIW KVAD EVGL RSVI EQFP GKLD FVLV DGGC VLSH GHKQ LMCL ARSV LSKA KILL LDEP SAHL DPVT YQII RRTL KQAF ADCT VILC EHRI EAML ECQQ FLVI EENK VRQY DSIQ KLLN ERSL FRQA ISPS DRVK LFPH RNSS KCKS KPQI AALK EETE EEVQ DTRL
Gene ID:1080
Uniprot:P13569
Cellular Location:Cell membrane, Early endosome membrane, Multi-pass membrane protein
Calculated MW:69kDa/161kDa/168kDa
Observed MW:186kDa
Synonyms:CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1
Background:This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene.
UniProt Protein Function:CFTR: a member of the MRP subfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. Functions as a chloride channel and controls the regulation of other transport pathways. Mutations have been observed in patients with the autosomal recessive disorders cystic fibrosis (CF) and congenital bilateral aplasia of the vas deferens (CBAVD). Alternative splice
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Channel, chloride; Transporter, ABC family; Membrane protein, integral; Transporter; Hydrolase; EC 3.6.3.49

Chromosomal Location of Human Ortholog: 7q31.2

Cellular Component: recycling endosome; cell surface; cytoplasmic vesicle membrane; microvillus; protein complex; early endosome membrane; basolateral plasma membrane; apical plasma membrane; early endosome; cytoplasm; plasma membrane

Molecular Function:bicarbonate transmembrane transporter activity; protein binding; chloride channel activity; enzyme binding; chloride channel inhibitor activity; chloride transmembrane transporter activity; channel-conductance-controlling ATPase activity; ATP-binding and phosphorylation-dependent chloride channel activity; ATP binding; PDZ domain binding

Biological Process: intracellular pH elevation; response to drug; response to peptide hormone stimulus; cholesterol transport; iodide transport; transepithelial chloride transport; water transport; membrane hyperpolarization; respiratory gaseous exchange; positive regulation of vasodilation; cholesterol biosynthetic process; vasodilation; cellular response to hormone stimulus; response to estrogen stimulus; bicarbonate transport; transport; response to cytokine stimulus; transmembrane transport; sperm capacitation; lung development

Disease: Vas Deferens, Congenital Bilateral Aplasia Of; Bronchiectasis With Or Without Elevated Sweat Chloride 1; Cystic Fibrosis; Pancreatitis, Hereditary

NCBI Summary:This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P13569
NCBI GenInfo Identifier:90421313
NCBI Gene ID:1080
NCBI Accession:NP_000483.3
UniProt Secondary Accession:P13569,Q20BG8, Q20BH2, Q2I0A1, Q2I102,
UniProt Related Accession:P13569
Molecular Weight:69,230 Da
NCBI Full Name:cystic fibrosis transmembrane conductance regulator
NCBI Synonym Full Names:cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
NCBI Official Symbol:CFTR  
NCBI Official Synonym Symbols:CF; MRP7; ABC35; ABCC7; CFTR/MRP; TNR-CFTR; dJ760C5.1  
NCBI Protein Information:cystic fibrosis transmembrane conductance regulator
UniProt Protein Name:Cystic fibrosis transmembrane conductance regulator
UniProt Synonym Protein Names:ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase (EC:3.6.3.49); cAMP-dependent chloride channel
Protein Family:Cystic fibrosis transmembrane conductance regulator
UniProt Gene Name:CFTR  
UniProt Entry Name:CFTR_HUMAN
Anti-CFTR Polyclonal Antibody (CAB8386)Western blot analysis of extracts of HL-60 cells, using CFTR antibody (CAB8386) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s.

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