The CHRNA4 Polyclonal Antibody (CAB1648) is a specialized research tool designed for studying the CHRNA4 protein, a subunit of the nicotinic acetylcholine receptor. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the CHRNA4 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential tool for researchers in the fields of neuroscience and pharmacology.The CHRNA4 protein is a key component of nicotinic acetylcholine receptors, which play a crucial role in neurotransmission and are implicated in various neurological disorders, including addiction, epilepsy, and cognitive dysfunction.
Understanding the function and regulation of CHRNA4 is essential for developing targeted therapies for these conditions and advancing our knowledge of neuronal communication.By using the CHRNA4 Polyclonal Antibody in your research, you can uncover new insights into the role of nicotinic acetylcholine receptors in neurological function and disease, ultimately contributing to the development of innovative treatments for a range of neurological disorders.
Product Name:
ACHA4 Rabbit Polyclonal Antibody
SKU:
CAB1648
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 29-242 of human ACHA4 (P43681).
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse kidney, using ACHA4 Rabbit pAb (CAB1648) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
