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Anti-ACHA4 Antibody (CAB0350)

SKU:
CAB0350
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
€139 - €419
Frequently bought together:

Description

Product Name:ACHA4 Rabbit mAb
Product Code:CAB0350
Size:20uL, 50uL, 100uL
Synonyms:BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ACHA4
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:C6, SH-SY5Y, Mouse liver, U-251MG, Mouse brain, Rat testis
Immunogen:A synthesized peptide derived from human ACHA4
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1137
Uniprot:P43681
Calculated MW:70kDa
Observed MW:70kDa
UniProt Protein Function:nAChRA4: a ligand-gated ion channels that binds acetylcholine and mediates fast signal transmission at synapses. After binding acetylcholine, these pentameric receptors undergo an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. An integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: cell soma; dendrite; external side of plasma membrane; membrane; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane

Molecular Function:acetylcholine binding; acetylcholine receptor activity; ligand-gated ion channel activity; nicotinic acetylcholine-activated cation-selective channel activity

Biological Process: B cell activation; behavioral response to nicotine; calcium ion transport; cognition; DNA repair; membrane depolarization; neurological system process; neuromuscular synaptic transmission; regulation of action potential; regulation of dopamine secretion; regulation of inhibitory postsynaptic membrane potential; regulation of membrane potential; response to hypoxia; response to nicotine; response to oxidative stress; sensory perception of pain; signal transduction; synaptic transmission, cholinergic

Disease: Epilepsy, Nocturnal Frontal Lobe, 1; Tobacco Addiction, Susceptibility To

NCBI Summary:This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
UniProt Code:P43681
NCBI GenInfo Identifier:1351848
NCBI Gene ID:1137
NCBI Accession:P43681.2
UniProt Secondary Accession:P43681,Q4JGR7, Q4VAQ5, Q4VAQ6,
UniProt Related Accession:P43681
Molecular Weight:60,994 Da
NCBI Full Name:Neuronal acetylcholine receptor subunit alpha-4
NCBI Synonym Full Names:cholinergic receptor nicotinic alpha 4 subunit
NCBI Official Symbol:CHRNA4  
NCBI Official Synonym Symbols:EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4  
NCBI Protein Information:neuronal acetylcholine receptor subunit alpha-4
UniProt Protein Name:Neuronal acetylcholine receptor subunit alpha-4
Protein Family:Neuronal acetylcholine receptor
UniProt Gene Name:CHRNA4  
UniProt Entry Name:ACHA4_HUMAN

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