The IRF5 Monoclonal Antibody (CAB11106) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, is validated for use in various applications such as Western blotting, immunohistochemistry, and immunofluorescence. It detects the IRF5 protein in human samples, enabling researchers to study its role in immune system function and inflammatory pathways.IRF5 is a transcription factor that plays a crucial role in the activation of inflammatory responses and immune cell differentiation. Dysregulation of IRF5 has been linked to autoimmune disorders, infectious diseases, and inflammatory conditions.
This antibody is validated for use in WB, IP, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
Product Name:
IRF5 Monoclonal Antibody
SKU:
CAB11106
Size:
20μL, 100μL
Reactivity:
Human, Mouse
Clone Number:
ARC0525
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment.
Purification Method
Affinity purification
Gene ID
3663
RRID
AB_2861503
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using IRF5 Rabbit mAb (CAB11106) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 5min.
Immunoprecipitation analysis of 600 μg extracts of Mouse thymus using 3 μg IRF5 antibody (CAB11106). Western blot was performed from the immunoprecipitate using IRF5 antibody (CAB11106) at a dilution of 1:500.
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