Cinrebafusp alfa (Research-Grade) is a research-grade biosimilar monoclonal antibody targeting CD137. It is a human IgG antibody. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays, in vivo research and Western blot. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB; Kd=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research.
Product Name:
Cinrebafusp alfa (Research-Grade)
SKU:
GXBS02437
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
CD340
Isotype:
IgG
Host Species:
Human
Reactivity:
Human
Applications:
ELISA, FCM, Functional assay, Research in vivo, WB
Humanized IgG1-kappa anti-human TCR Vβ6/β10 monomer disulfide bridged to human IL-2 fragment fused via (G4S)2 peptide linker to immunoglobulin G1 Fc fragment.
