ApplicationsELISA, Functional assay, Research in vivo
IsotypeHumanized IgG1-kappa anti-human TCR Vβ6/β10 monomer disulfide bridged to human IL-2 fragment fused via (G4S)2 peptide linker to immunoglobulin G1 Fc fragment.
SKU:
GXBS02356
UPC:
Product Type:
Research Grade Biosimilar
Host Species:
Human
Reactivity:
Human
Applications:
ELISA, Functional assay, Research in vivo
Isotype:
Humanized IgG1-kappa anti-human TCR Vβ6/β10 monomer disulfide bridged to human IL-2 fragment fused via (G4S)2 peptide linker to immunoglobulin G1 Fc fragment.
Invikafusp Alfa (Research-Grade) is a research-grade biosimilar antibody targeting IL2. Reactivity: Human. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Interleukin-2 (TCR Vβ6/β10 & IL2) is a ~17 kDa protein. Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.
Product Name:
Invikafusp Alfa (Research-Grade)
SKU:
GXBS02356
Size:
100 µg, 1 mg
Target:
IL2
Isotype:
Humanized IgG1-kappa anti-human TCR Vβ6/β10 monomer disulfide bridged to human IL-2 fragment fused via (G4S)2 peptide linker to immunoglobulin G1 Fc fragment.
Host Species:
Human
Reactivity:
Human
Applications:
ELISA, Functional assay, Research in vivo
Expression Host:
Mammalian cells
Synonyms:
2894138-60-2
Purity:
>95% purity as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Human alkaline phosphatase, tissue-nonspecific isozyme/AP-TNAP soluble fragment fused to a human immunoglobulin G4 heavy chain constant region fragment fused to a deca-aspartate peptide, disulfide bridged dimer.
human glucagonlike peptide 1 receptor, GLP1R fused at the N-terminus of each light chain (53-266) via the peptide linker 30GSGSATGGSGSGASSGSGSATGS52 to a glucagon-like peptide-1 (GLP-1) fragment
