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Key Features

COMP Monoclonal Antibody (CAB22260)

Datasheet MSDS
SKU CAB22260
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse, Rat
Host Species Rabbit
Synonyms MED, CTS2, EDM1, EPD1, TSP5, PSACH, THBS5, TSP-5, COMP
€131 - €457

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Description

system_update_altDatasheetsystem_update_altMSDS

COMP Monoclonal Antibody (CAB22260)

The COMP Monoclonal Antibody (CAB22260) is a high-quality antibody developed for reliable detection and analysis of target proteins. This monoclonal antibody, produced using cutting-edge technology, is highly specific and sensitive for detecting COMP in various sample types. Its compatibility with techniques like immunohistochemistry and ELISA makes it versatile for a wide range of research applications in orthopedics, rheumatology, and musculoskeletal biology.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse, Rat samples.

Product Name:COMP Monoclonal Antibody
SKU:CAB22260
Size:20μL, 100μL
Reactivity:Mouse, Rat
Clone Number:ARC54617
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:ELLR QQVR EITF LKNT VMEC DACG MQQS VRTG LPSV RPLL HCAP GFCF PGVA CIQT ESGA RCGP CPAG FTGN GSHC TDVN ECNA HPCF PRVR CINT SPGF R
Tested Applications:WB ELISA
Recommended Dilution:
WB1:1000 - 1:5000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:MED, CTS2, EDM1, EPD1, TSP5, PSACH, THBS5, TSP-5, COMP
Positive Sample:Mouse articular cartilage, Rat articar cartilage
Cellular Localization:Secreted, Extracellular Matrix, Extracellular Space.
Calculated MW:83kDa
Observed MW:100kDa

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).

Purification MethodAffinity purification
Gene ID1311
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using COMP Rabbit mAb (CAB22260) at 1:5000 dilution incubated overnight at 4℃. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Negative control (NC): Mouse liver, Rat liver. Exposure time: 90 s.
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