The Complexin-2 Polyclonal Antibody (CAB7774) is a vital tool for researchers studying Complexin-2, a protein essential for neurotransmitter release and synaptic vesicle fusion. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for a variety of experimental applications, including Western blotting.Complexin-2 is a key regulator of synaptic vesicle exocytosis and neurotransmitter release, playing a crucial role in neuronal communication and signal transmission. Dysregulation of Complexin-2 has been linked to neurological disorders such as epilepsy, schizophrenia, and Parkinson's disease, highlighting its importance in maintaining proper brain function.
By using the Complexin-2 Polyclonal Antibody, researchers can investigate the expression levels and localization of Complexin-2 in different cell types and tissues, deepening our understanding of its physiological functions and pathological implications. This antibody is a valuable resource for studies aimed at unraveling the molecular mechanisms underlying synaptic transmission and identifying potential therapeutic targets for neurological diseases.
Product Name:
CPLX2 Rabbit Polyclonal Antibody
SKU:
CAB7774
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human CPLX2 (NP_006641.1).
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10814
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CPLX2 antibody (CAB7774) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
