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Anti-CSNK2A2 Antibody (CAB13481)

SKU:
CAB13481
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • Cell Death Antibodies 1 Anti-CSNK2A2 Antibody CAB13481
  • Cell Death Antibodies 1 Anti-CSNK2A2 Antibody CAB13481
  • Cell Death Antibodies 1 Anti-CSNK2A2 Antibody CAB13481
  • Cell Death Antibodies 1 Anti-CSNK2A2 Antibody CAB13481
  • Cell Death Antibodies 1 Anti-CSNK2A2 Antibody CAB13481
€139 - €419
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Description

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Antibody Name:Anti-CSNK2A2 Antibody
Antibody SKU:CAB13481
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human CSNK2A2 (NP_001887.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:K-562, Mouse testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human CSNK2A2 (NP_001887.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPGP AAGS RARV YAEV NSLR SREY WDYE AHVP SWGN QDDY QLVR KLGR GKYS EVFE AINI TNNE RVVV KILK PVKK KKIK REVK ILEN LRGG TNII KLID TVKD PVSK TPAL VFEY INNT DFKQ LYQI LTDF DIRF YMYE LLKA LDYC HSKG IMHR DVKP HNVM IDHQ QKKL RLID WGLA EFYH PAQE YNVR VASR YFKG PELL VDYQ MYDY SLDM WSLG CMLA SMIF RREP FFHG QDNY DQLV RIAK VLGT EELY GYLK KYHI DLDP HFND ILGQ HSRK RWEN FIHS ENRH LVSP EALD LLDK LLRY DHQQ RLTA KEAM EHPY FYPV VKEQ SQPC ADNA VLSS GLTA AR
Gene ID:1459
Uniprot:P19784
Cellular Location:
Calculated MW:41kDa
Observed MW:38kDa
Synonyms:CSNK2A2, CK2A2, CK2alpha, CSNK2A1
Background:
UniProt Protein Function:CK2A2: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
UniProt Protein Details:

Protein type:Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; CK2 family

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: PcG protein complex; nucleus; cytosol

Molecular Function:protein serine/threonine kinase activity; protein binding; protein N-terminus binding; ATP binding

Biological Process: axon guidance; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptosis; mitotic cell cycle; protein amino acid phosphorylation

NCBI Summary:This gene encodes the alpha', or alpha 2, catalytic subunit of the protein kinase enzyme, casein kinase 2 (CK2). Casein kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. This heterotetrameric kinase includes two catalytic subunits, either alpha or alpha', and two regulatory beta subunits. The closely related gene paralog encoding the alpha, or alpha 1 subunit (CSNK2A1, Gene ID: 1457) is found on chromosome 20. An intronic variant in this gene (alpha 2) may be associated with leukocyte telomere length in a South Asian population. A related transcribed pseudogene is found on chromosome 11. [provided by RefSeq, Aug 2017]
UniProt Code:P19784
NCBI GenInfo Identifier:125266
NCBI Gene ID:1459
NCBI Accession:P19784.1
UniProt Related Accession:P19784
Molecular Weight:
NCBI Full Name:Casein kinase II subunit alpha'
NCBI Synonym Full Names:casein kinase 2 alpha 2
NCBI Official Symbol:CSNK2A2  
NCBI Official Synonym Symbols:CK2A2; CSNK2A1; CK2alpha'  
NCBI Protein Information:casein kinase II subunit alpha'
UniProt Protein Name:Casein kinase II subunit alpha'
Protein Family:Protein
UniProt Gene Name:CSNK2A2  
UniProt Entry Name:CSK22_HUMAN
Anti-CSNK2A2 Antibody (CAB13481)Western blot analysis of extracts of various cell lines, using CSNK2A2 antibody (CAB13481) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-CSNK2A2 Antibody (CAB13481)Immunohistochemistry of paraffin-embedded rat lung using CSNK2A2 antibody (CAB13481) at dilution of 1:100 (40x lens).
Anti-CSNK2A2 Antibody (CAB13481)Immunohistochemistry of paraffin-embedded human lung cancer using CSNK2A2 antibody (CAB13481) at dilution of 1:100 (40x lens).
Anti-CSNK2A2 Antibody (CAB13481)Immunohistochemistry of paraffin-embedded human liver cancer using CSNK2A2 antibody (CAB13481) at dilution of 1:100 (40x lens).
Anti-CSNK2A2 Antibody (CAB13481)Immunohistochemistry of paraffin-embedded mouse lung using CSNK2A2 antibody (CAB13481) at dilution of 1:100 (40x lens).

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