Anti-CSRNP1 Antibody (CAB7130)

Antibody Name:	Anti-CSRNP1 Antibody
Antibody SKU:	CAB7130
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CSRNP1 (NP_149016.2).

Application:	WB IHC IF
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Reactivity:	Human, Mouse, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CSRNP1 (NP_149016.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MTGL LKRK FDQL DEDN SSVS SSSS SSGC QSRS CSPS SSVS RAWD SEEE GPWD QMPL PDRD FCGP RSFT PLSI LKRA RRER PGRV AFDG ITVF YFPR CQGF TSVP SRGG CTLG MALR HSAC RRFS LAEF AQEQ ARAR HEKL RQRL KEEK LEML QWKL SAAG VPQA EAGL PPVV DAID DASV EEDL AVAV AGGR LEEV SFLQ
Gene ID:	64651
Uniprot:	Q96S65
Cellular Location:	Nucleus
Calculated MW:	63kDa
Observed MW:	Refer to figures

Synonyms:

CSRNP1, AXUD1, CSRNP-1, FAM130B, TAIP-3, URAX1

Background:

This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	AXUD1: Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. May have a tumor-suppressor function. May play a role in apoptosis. Belongs to the AXUD1 family.
UniProt Protein Details:	Chromosomal Location of Human Ortholog: 3p22 Cellular Component: nucleus Molecular Function:sequence-specific DNA binding; transcription factor activity Biological Process: transcription, DNA-dependent; apoptosis; skeletal morphogenesis; platelet-derived growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; palate development; post-embryonic development
NCBI Summary:	This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. [provided by RefSeq, Jul 2008]
UniProt Code:	Q96S65
NCBI GenInfo Identifier:	308153432
NCBI Gene ID:	64651
NCBI Accession:	Q96S65.2
UniProt Secondary Accession:	Q96S65,Q69YY5,
UniProt Related Accession:	Q96S65
Molecular Weight:	589
NCBI Full Name:	Cysteine/serine-rich nuclear protein 1
NCBI Synonym Full Names:	cysteine-serine-rich nuclear protein 1
NCBI Official Symbol:	CSRNP1
NCBI Official Synonym Symbols:	AXUD1; URAX1; TAIP-3; CSRNP-1; FAM130B
NCBI Protein Information:	cysteine/serine-rich nuclear protein 1; AXIN1 up-regulated 1; axin-1 up-regulated gene 1 protein; TGF-beta induced apoptosis protein 3; TGF-beta-induced apoptosis protein 3
UniProt Protein Name:	Cysteine/serine-rich nuclear protein 1
UniProt Synonym Protein Names:	Axin-1 up-regulated gene 1 protein; Protein URAX1; TGF-beta-induced apoptosis protein 3; TAIP-3
Protein Family:	Cysteine/serine-rich nuclear protein
UniProt Gene Name:	CSRNP1
UniProt Entry Name:	CSRN1_HUMAN

	Immunohistochemistry of paraffin-embedded rat kidney using CSRNP1 antibody (CAB7130) at dilution of 1:200 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse brain using CSRNP1 antibody (CAB7130) at dilution of 1:200 (40x lens).
	Immunofluorescence analysis of A549 cells using CSRNP1 antibody (CAB7130).

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)