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Anti-CTPS1 Antibody (CAB3817)

SKU:
CAB3817
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
€139 - €419
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Description

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Antibody Name:Anti-CTPS1 Antibody
Antibody SKU:CAB3817
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 402-591 of human CTPS1 (NP_001896.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Raji, HeLa, 22Rv1, Jurkat, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 402-591 of human CTPS1 (NP_001896.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MQLA VVEF SRNV LGWQ DANS TEFD PTTS HPVV VDMP EHNP GQMG GTMR LGKR RTLF QTKN SVMR KLYG DADY LEER HRHR FEVN PVWK KCLE EQGL KFVG QDVE GERM EIVE LEDH PFFV GVQY HPEF LSRP IKPS PPYF GLLL ASVG RLSH YLQK GCRL SPRD TYSD RSGS SSPD SEIT ELKF PSIN HD
Gene ID:1503
Uniprot:P17812
Cellular Location:
Calculated MW:41kDa/66kDa
Observed MW:80kDa
Synonyms:CTPS1, CTPS, GATD5, IMD24
Background:This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:CTPS: the enzyme cytidine-5-prime-triphosphate synthetase converts UTP to CTP. Important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints involved in several tumor types.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; EC 6.3.4.2; Nucleotide Metabolism - pyrimidine; Ligase

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: membrane; cytosol

Molecular Function:CTP synthase activity; ATP binding

Biological Process: T cell proliferation; B cell proliferation; response to drug; CTP biosynthetic process; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; glutamine metabolic process

Disease: Immunodeficiency 24

NCBI Summary:This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Code:P17812
NCBI GenInfo Identifier:20981706
NCBI Gene ID:1503
NCBI Accession:P17812.2
UniProt Related Accession:P17812
Molecular Weight:~ 67kDa
NCBI Full Name:CTP synthase 1
NCBI Synonym Full Names:CTP synthase 1
NCBI Official Symbol:CTPS1  
NCBI Official Synonym Symbols:CTPS; GATD5; IMD24  
NCBI Protein Information:CTP synthase 1
UniProt Protein Name:CTP synthase 1
UniProt Synonym Protein Names:CTP synthetase 1; UTP--ammonia ligase 1
UniProt Gene Name:CTPS1  
UniProt Entry Name:PYRG1_HUMAN
Anti-CTPS1 Antibody (CAB3817)Western blot analysis of extracts of various cell lines, using CTPS1 antibody (CAB3817) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.

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