The CXCR4 Antibody (CAB1303) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it ideal for use in Western blotting and immunohistochemistry applications.CXCR4, also known as C-X-C chemokine receptor type 4, plays a crucial role in immune cell trafficking and homing to specific tissues through its interaction with the chemokine ligand CXCL12. Dysregulation of the CXCR4/CXCL12 axis has been linked to various diseases, including cancer, HIV/AIDS, and inflammatory conditions.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
Product Name:
CXCR4 Antibody
SKU:
CAB1303
Size:
20μL, 100μL
Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Cell Junction, Cell Membrane, Early Endosome, Late Endosome, Lysosome, Multi-Pass Membrane Protein.
Calculated MW:
40kDa
Observed MW:
36kDa/70kDa
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method
Affinity purification
Gene ID
7852
RRID
AB_2759877
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using CXCR4 Rabbit pAb (CAB1303) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
