DBH Rabbit Polyclonal Antibody (CAB2711)
- SKU:
- CAB2711
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
Product Name: | DBH Rabbit Polyclonal Antibody |
SKU: | CAB2711 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-200 of human DBH (NP_958852.1). |
Sequence: | MAKE RGLI SPSD FAQL QKYM EYST KKVS DVLK LFED GEMA KYVQ GDAI GYEG FQQF LKIY LEVD NVPR HLSL ALFQ SFET GHCL NETN VTKD VVCL NDVS CYFS LLEG GRPE DKLE FTFK LYDT DRNG ILDS SEVD KIIL QMMR VAEY LDWD VSEL RPIL QEMM KEID YDGS GSVS QAEW VRAG ATTV PLLV LLGL EMTL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | DBM; ORTHYP1; DBH |
Positive Sample: | Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasmic vesicle, Single-pass type II membrane protein, chromaffin granule lumen, chromaffin granule membrane, secretory vesicle, secretory vesicle lumen, secretory vesicle membrane. |
Calculated MW: | 69kDa |
Observed MW: | 79kDa |
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders.
Purification Method: | Affinity purification |
Gene ID: | 1621 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |