DBH Rabbit Polyclonal Antibody (CAB13971)
- SKU:
- CAB13971
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | DBH Rabbit Polyclonal Antibody |
SKU: | CAB13971 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 388-617 of human DBH (NP_000778.3). |
Sequence: | GYCT DKCT QLAL PPSG IHIF ASQL HTHL TGRK VVTV LVRD GREW EIVN QDNH YSPH FQEI RMLK KVVS VHPG DVLI TSCT YNTE DREL ATVG GFGI LEEM CVNY VHYY PQTQ LELC KSAV DAGF LQKY FHLI NRFN NEDV CTCP QASV SQQF TSVP WNSF NRDV LKAL YSFA PISM HCNK SSAV RFQG EWNL QPLP KVIS TLEE PTPQ CPTS QGRS PAGP TVVS IGGG KG |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 |
Synonyms: | DBM; ORTHYP1; DBH |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasmic vesicle, Single-pass type II membrane protein, chromaffin granule lumen, chromaffin granule membrane, secretory vesicle, secretory vesicle lumen, secretory vesicle membrane. |
Calculated MW: | 69kDa |
Observed MW: | Refer to figures |
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders.
Purification Method: | Affinity purification |
Gene ID: | 1621 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |