Description
Dopamine beta Hydroxylase Monoclonal Antibody (CAB23579)
The Dopamine beta Hydroxylase Monoclonal Antibody (CAB23579) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced from mouse monoclonal cells, is highly specific and reactive with human samples, making it ideal for use in various research applications.DBH plays a crucial role in the regulation of neurotransmitters in the brain and has been implicated in several neurological disorders, including Parkinson's disease and schizophrenia.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
| Product Name: | Dopamine beta Hydroxylase Monoclonal Antibody |
| SKU: | CAB23579 |
| Size: | 20μL, 100μL |
| Reactivity: | Human |
| Clone Number: | ARC3095 |
| Conjugate: | Unconjugated |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. | ||||
| Sequence: | LVVL WTDG DTAY FADA WSDQ KGQI HLDP QQDY QLLQ VQRT PEGL TLLF KRPF GTCD PKDY LIED GTVH LVYG ILEE PFRS LEAI NGSG LQMG LQRV QLLK PNIP EPEL PSDA CTME VQAP NIQI PSQE TTYW CYIK ELPK GFSR HHII KYE | ||||
| Tested Applications: | WB ELISA | ||||
| Recommended Dilution: |
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| Synonyms: | DBM, ORTHYP1, Dopamine beta Hydroxylase |
| Positive Sample: | SH-SY5Y |
| Cellular Localization: | Cytoplasmic Vesicle, Single-Pass Type Ii Membrane Protein, Chromaffin Granule Lumen, Chromaffin Granule Membrane, Secretory Vesicle, Secretory Vesicle Lumen, Secretory Vesicle Membrane. |
| Calculated MW: | 69kDa |
| Observed MW: | 75-80kDa |
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders.
| Purification Method | Affinity purification |
| Gene ID | 1621 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3. |
 | Western blot analysis of various lysates using Dopamine beta Hydroxylase Rabbit mAb (CAB23579) at 1:1000 dilution incubated overnight at 4℃. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Negative control (NC): 293T Exposure time: 30s. |
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