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Cell Death Antibodies 2 Anti-DR5 Antibody CAB19043
Key Features

DR5/TRAILR2/TNFRSF10B Rabbit Monoclonal Antibody (CAB19043)

Datasheet MSDS
SKU CAB19043
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human, Mouse, Rat
Host Species Rabbit
Synonyms DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5, DR5/TRAILR2/TNFRSF10B
Research Use Cell Death
$173 - $603

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Description

system_update_altDatasheetsystem_update_altMSDS

DR5/TRAILR2/TNFRSF10B Monoclonal Antibody (CAB19043)

The DR5/TRAILR2/TNFRSF10B Monoclonal Antibody (CAB19043) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blotting and immunohistochemistry applications.DR5, also known as TNFRSF10B, is a member of the tumor necrosis factor receptor superfamily and is involved in apoptosis, particularly in response to treatment with certain chemotherapeutic drugs.

This antibody is validated for use in WB, IHC-P, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:DR5/TRAILR2/TNFRSF10B Monoclonal Antibody
SKU:CAB19043
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Clone Number:ARC0406
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:CFDD FADL VPFD SWEP LMRK LGLM DNEI KVAK AEAA GHRD TLYT MLIK WVNK TGRD ASVH TLLD ALET LGER LAKQ KIED HLLS SGKF MYLE GNAD SAMS
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:
WB1:1000 - 1:2000
IHC-P1:200 - 1:800
IF/ICC1:100 - 1:400
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5, DR5/TRAILR2/TNFRSF10B
Positive Sample:Mouse heart, Mouse lung, Rat lung
Cellular Localization:Membrane, Single-Pass Type I Membrane Protein.
Calculated MW:48kDa
Observed MW:48kDa

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.

Purification MethodAffinity purification
Gene ID8795
RRIDAB_2862536
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from Mouse heart, using DR5/TRAILR2/TNFRSF10B Rabbit mAb (CAB19043) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
Product ImageWestern blot analysis of various lysates using DR5/TRAILR2/TNFRSF10B Rabbit mAb (CAB19043) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 3min.
Product ImageConfocal imaging of NIH-3T3 cells using DR5/TRAILR2/TNFRSF10B Rabbit mAb (CAB19043,dilution 1:100)(Red). The cells were counterstained with α-Tubulin Mouse mAb (AC012,dilution 1:400) (Green). DAPI was used for nuclear staining (blue). Objective: 100x.
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