Description
DUSP4 Antibody (CAB2726)
The DUSP4 Antibody (CAB2726) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.DUSP4, also known as MAPK phosphatase 2 (MKP-2), plays a crucial role in fine-tuning MAP kinase signaling by dephosphorylating and inactivating MAP kinases. Dysregulation of DUSP4 has been implicated in various diseases, including cancer, cardiovascular disorders, and neurological conditions.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
| Product Name: | DUSP4 Antibody |
| SKU: | CAB2726 |
| Size: | 20μL, 100μL |
| Reactivity: | Human |
| Conjugate: | Unconjugated |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. | ||||
| Sequence: | MVTM EELR EMDC SVLK RLMN RDEN GGGA GGSG SHGT LGLP SGGK CLLL DCRP FLAH SAGY ILGS VNVR CNTI VRRR AKGS VSLE QILP AEEE VRAR LRSG LYSA VIVY DERS PRAE SLRE DSTV SLVV QALR RNAE RTDI CLLK GGYE RFSS EYPE FCSK TKAL AAIP | ||||
| Tested Applications: | WB ELISA | ||||
| Recommended Dilution: |
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| Synonyms: | TYP, HVH2, MKP2, MKP-2, DUSP4 |
| Positive Sample: | COS-7, HeLa, A375 |
| Cellular Localization: | Nucleus. |
| Calculated MW: | 43kDa |
| Observed MW: | 47kDa |
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.
| Purification Method | Affinity purification |
| Gene ID | 1846 |
| RRID | AB_2764577 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |
 | Western blot analysis of various lysates using DUSP4 Rabbit pAb (CAB2726) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s. |
