| Background: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. |
| NCBI Summary: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014] |
| UniProt Code: | Q16828 |
| NCBI GenInfo Identifier: | 108860971 |
| NCBI Gene ID: | 1848 |
| NCBI Accession: | Q16828.2 |
| UniProt Secondary Accession: | Q16828,O75109, Q53Y75, Q9BSH6, |
| UniProt Related Accession: | Q16828 |
| Molecular Weight: | 26,468 Da |
| NCBI Full Name: | Dual specificity protein phosphatase 6 |
| NCBI Synonym Full Names: | dual specificity phosphatase 6 |
| NCBI Official Symbol: | DUSP6Â Â |
| NCBI Official Synonym Symbols: | HH19; MKP3; PYST1Â Â |
| NCBI Protein Information: | dual specificity protein phosphatase 6 |
| UniProt Protein Name: | Dual specificity protein phosphatase 6 |
| UniProt Synonym Protein Names: | Dual specificity protein phosphatase PYST1; Mitogen-activated protein kinase phosphatase 3; MAP kinase phosphatase 3; MKP-3 |
| Protein Family: | Dual specificity protein phosphatase |
| UniProt Gene Name: | DUSP6Â Â |
| UniProt Entry Name: | DUS6_HUMAN |
