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Anti-DYNC1I1 Antibody (CAB3833)

SKU:
CAB3833
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
  • Signal Transduction Antibodies 2 Anti-DYNC1I1 Antibody CAB3833
  • Signal Transduction Antibodies 2 Anti-DYNC1I1 Antibody CAB3833
  • Signal Transduction Antibodies 2 Anti-DYNC1I1 Antibody CAB3833
€139 - €419
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Description

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Antibody Name:Anti-DYNC1I1 Antibody
Antibody SKU:CAB3833
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human DYNC1I1 (NP_001129028.1).
Application:WB IHC
Recommended Dilution:WB 1:200 - 1:2000 IHC 1:20 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, SH-SY5Y, HeLa, Mouse testis, Mouse brain, Mouse skeletal muscle, Rat brain, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human DYNC1I1 (NP_001129028.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSDK SDLK AELE RKKQ RLAQ IREE KKRK EEER KKKE ADMQ QKKE PVQD DSDL DRKR RETE ALLQ SIGI SPEP PLVP TPMS PSSK SVST PSEA GSQD SGDL GPLT RTLQ WDTD PSVL QLQS DSEL GRRL HKLG VSKV TQVD FLPR EVVS YSKE TQTP LATH QSEE DEED EEMV ESKV GQDS ELEN QDKK QEVK EAPP RELT EEEK QQIL HSEE FLIF FDRT
Gene ID:1780
Uniprot:O14576
Cellular Location:Chromosome, Cytoplasm, centromere, cytoskeleton, kinetochore, spindle pole
Calculated MW:67kDa/68kDa/70kDa/72kDa
Observed MW:73kDa
Synonyms:DYNC1I1, DNCI1, DNCIC1
Background:
UniProt Protein Function:DYNC1I1: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores. Belongs to the dynein intermediate chain family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Microtubule-binding; Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: kinetochore; spindle pole; microtubule; recycling endosome; cytoplasmic dynein complex; perinuclear region of cytoplasm; cytosol; vesicle

Molecular Function:protein binding; spectrin binding; microtubule binding; motor activity; microtubule motor activity

Biological Process: metabolic process; vesicle transport along microtubule; antigen processing and presentation of exogenous peptide antigen via MHC class II

UniProt Code:O14576
NCBI GenInfo Identifier:6647481
NCBI Gene ID:1780
NCBI Accession:O14576.2
UniProt Related Accession:O14576
Molecular Weight:Observed Molecular Weight: (Observed)72kD.Predicted Molecular Weight: (Calculated)73kDa.
NCBI Full Name:Cytoplasmic dynein 1 intermediate chain 1
NCBI Synonym Full Names:dynein cytoplasmic 1 intermediate chain 1
NCBI Official Symbol:DYNC1I1  
NCBI Official Synonym Symbols:DNCI1; DNCIC1  
NCBI Protein Information:cytoplasmic dynein 1 intermediate chain 1
UniProt Protein Name:Cytoplasmic dynein 1 intermediate chain 1
UniProt Synonym Protein Names:Cytoplasmic dynein intermediate chain 1; Dynein intermediate chain 1, cytosolic; DH IC-1
Protein Family:Cytoplasmic dynein
UniProt Gene Name:DYNC1I1  
UniProt Entry Name:DC1I1_HUMAN
Anti-DYNC1I1 Antibody (CAB3833)Western blot analysis of extracts of various cell lines, using DYNC1I1 antibody (CAB3833) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
Anti-DYNC1I1 Antibody (CAB3833)Immunohistochemistry of paraffin-embedded human stomach using DYNC1I1 antibody (CAB3833) at dilution of 1:100 (40x lens).
Anti-DYNC1I1 Antibody (CAB3833)Immunohistochemistry of paraffin-embedded rat brain using DYNC1I1 antibody (CAB3833) at dilution of 1:100 (40x lens).

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