Anti-EEA1 Antibody (CAB5057)
- SKU:
- CAB5057
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MST105
- MSTP105
- ZFYVE2
- Research Area:
- Cell Biology
Description
| Product Name: | EEA1 Rabbit mAb |
| Product Code: | CAB5057 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | MST105, MSTP105, ZFYVE2 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human EEA1 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | C6, U-251MG, Mouse brain |
| Immunogen: | A synthesized peptide derived from human EEA1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8411 |
| Uniprot: | Q15075 |
| Calculated MW: | 170kDa |
| Observed MW: | 170KDa |
| UniProt Protein Function: | Function: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
| UniProt Protein Details: | Subunit structure: Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding. Interacts with RAB31. Interacts with ERBB2. May interact with PLEKHF2. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.17 Ref.18 Subcellular location: Cytoplasm. Early endosome membrane; Peripheral membrane protein Ref.1 Ref.7 Ref.9 Ref.13 Ref.17. Domain: The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns3P-enriched membranes is substantially increased in acidic conditions. Ref.14 Miscellaneous: Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases. Sequence similarities: Contains 1 C2H2-type zinc finger.Contains 1 FYVE-type zinc finger. |
| UniProt Code: | Q15075 |
| NCBI GenInfo Identifier: | 55770888 |
| NCBI Gene ID: | 8411 |
| NCBI Accession: | NP_003557.2 |
| UniProt Secondary Accession: | Q15075,Q14221, |
| UniProt Related Accession: | Q15075 |
| Molecular Weight: | 162,466 Da |
| NCBI Full Name: | early endosome antigen 1 |
| NCBI Synonym Full Names: | early endosome antigen 1 |
| NCBI Official Symbol: | EEA1Â Â |
| NCBI Official Synonym Symbols: | MST105; ZFYVE2; MSTP105Â Â |
| NCBI Protein Information: | early endosome antigen 1; early endosome antigen 1, 162kD; endosome-associated protein p162; early endosome-associated protein; zinc finger FYVE domain-containing protein 2 |
| UniProt Protein Name: | Early endosome antigen 1 |
| UniProt Synonym Protein Names: | Endosome-associated protein p162; Zinc finger FYVE domain-containing protein 2 |
| Protein Family: | Early endosome antigen |
| UniProt Gene Name: | EEA1Â Â |
| UniProt Entry Name: | EEA1_HUMAN |
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