null

Anti-EIF2AK3 Antibody (CAB18196)

SKU:
CAB18196
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism
  • Metabolism Antibodies 3 Anti-EIF2AK3 Antibody CAB18196
  • Metabolism Antibodies 3 Anti-EIF2AK3 Antibody CAB18196
  • Metabolism Antibodies 3 Anti-EIF2AK3 Antibody CAB18196
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-EIF2AK3 Antibody
Antibody SKU:CAB18196
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human EIF2AK3
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa
Immunogen:Recombinant protein of human EIF2AK3
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9451
Uniprot:Q9NZJ5
Cellular Location:Endoplasmic reticulum membrane, Single-pass type I membrane protein
Calculated MW:125kDa
Observed MW:160kDa
Anti-EIF2AK3 Antibody (CAB18196)Western blot analysis of extracts of HeLa cells, using EIF2AK3 antibody (CAB18196) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s.
Anti-EIF2AK3 Antibody (CAB18196)Immunofluorescence analysis of C6 cells using EIF2AK3 Rabbit pAb (CAB18196) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Anti-EIF2AK3 Antibody (CAB18196)Immunofluorescence analysis of L929 cells using EIF2AK3 Rabbit pAb (CAB18196) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Synonyms:EIF2AK3, PEK, PERK, WRS
Background:The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
NCBI Summary:The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]
UniProt Code:Q9NZJ5
NCBI GenInfo Identifier:296439367
NCBI Gene ID:9451
NCBI Accession:
UniProt Related Accession:Q9NZJ5
Molecular Weight:170
NCBI Full Name:Eukaryotic translation initiation factor 2-alpha kinase 3
NCBI Synonym Full Names:eukaryotic translation initiation factor 2 alpha kinase 3
NCBI Official Symbol:EIF2AK3  
NCBI Official Synonym Symbols:PEK; WRS; PERK  
NCBI Protein Information:eukaryotic translation initiation factor 2-alpha kinase 3
UniProt Protein Name:
UniProt Gene Name:

Related Products