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Anti-ELAVL2 Antibody (CAB5918)

SKU:
CAB5918
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 9 Anti-ELAVL2 Antibody CAB5918
  • Cell Biology Antibodies 9 Anti-ELAVL2 Antibody CAB5918
  • Cell Biology Antibodies 9 Anti-ELAVL2 Antibody CAB5918
  • Cell Biology Antibodies 9 Anti-ELAVL2 Antibody CAB5918
€139 - €419
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Description

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Antibody Name:Anti-ELAVL2 Antibody
Antibody SKU:CAB5918
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ELAVL2 (NP_004423.2).
Application:WB IHC IF
Recommended Dilution:WB 1:1000 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, Mouse spinal cord
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ELAVL2 (NP_004423.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:METQ LSNG PTCN NTAN GPTT INNN CSSP VDSG NTED SKTN LIVN YLPQ NMTQ EELK SLFG SIGE IESC KLVR DKIT GQSL GYGF VNYI DPKD AEKA INTL
Gene ID:1993
Uniprot:Q12926
Cellular Location:
Calculated MW:38kDa/39kDa
Observed MW:44kDa
Synonyms:ELAVL2, HEL-N1, HELN1, HUB
Background:The protein encoded by this gene is a neural-specific RNA-binding protein that is known to bind to several 3' UTRs, including its own and also that of FOS and ID. The encoded protein may recognize a GAAA motif in the RNA. Three transcript variants encoding two different isoforms have been found for this gene.
UniProt Protein Function:ELAVL2: Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR. Belongs to the RRM elav family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA-binding

Chromosomal Location of Human Ortholog: 9p21.3

Cellular Component: nucleoplasm

Molecular Function:mRNA 3'-UTR binding; protein binding; RNA binding

Biological Process: nuclear mRNA splicing, via spliceosome; regulation of transcription, DNA-dependent

NCBI Summary:The protein encoded by this gene is a neural-specific RNA-binding protein that is known to bind to several 3' UTRs, including its own and also that of FOS and ID. The encoded protein may recognize a GAAA motif in the RNA. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
UniProt Code:Q12926
NCBI GenInfo Identifier:93141258
NCBI Gene ID:1993
NCBI Accession:Q12926.2
UniProt Secondary Accession:Q12926,Q13235, Q59G15, Q8NEM4, Q9H1Q8, D3DRK3,
UniProt Related Accession:Q12926
Molecular Weight:40kDa
NCBI Full Name:ELAV-like protein 2
NCBI Synonym Full Names:ELAV like RNA binding protein 2
NCBI Official Symbol:ELAVL2  
NCBI Official Synonym Symbols:HUB; HELN1; HEL-N1  
NCBI Protein Information:ELAV-like protein 2
UniProt Protein Name:ELAV-like protein 2
UniProt Synonym Protein Names:ELAV-like neuronal protein 1; Hu-antigen B; HuB; Nervous system-specific RNA-binding protein Hel-N1
Protein Family:ELAV-like protein
UniProt Gene Name:ELAVL2  
Anti-ELAVL2 Antibody (CAB5918)Western blot analysis of extracts of various cell lines, using ELAVL2 antibody (CAB5918) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-ELAVL2 Antibody (CAB5918)Immunohistochemistry of paraffin-embedded rat brain using ELAVL2 antibody (CAB5918) at dilution of 1:200 (40x lens).
Anti-ELAVL2 Antibody (CAB5918)Immunohistochemistry of paraffin-embedded mouse brain using ELAVL2 antibody (CAB5918) at dilution of 1:200 (40x lens).
Anti-ELAVL2 Antibody (CAB5918)Immunofluorescence analysis of U2OS cells using ELAVL2 antibody (CAB5918) at dilution of 1:100. Blue: DAPI for nuclear staining.

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