Description
Elk1 Transcription Factor Activity Assay
The Elk1 Transcription Factor Activity Assay offered by AssayGenie is a cutting-edge kit designed to accurately measure the activity of the Elk1 transcription factor in various biological samples. This assay boasts high sensitivity and specificity, ensuring precise and reproducible results for researchers studying gene expression regulation.Elk1 is a key transcription factor that plays a critical role in cell growth, differentiation, and response to external stimuli. Dysregulation of Elk1 activity has been implicated in a variety of diseases, including cancer, inflammatory disorders, and neurological conditions.
By using the Elk1 Transcription Factor Activity Assay, researchers can gain valuable insights into the molecular mechanisms underlying these diseases and identify potential therapeutic targets.Whether you are investigating signal transduction pathways, studying gene regulation in disease models, or exploring the role of transcription factors in cell function, the Elk1 Transcription Factor Activity Assay is the perfect tool to advance your research. Order yours today and unlock new discoveries in the field of molecular biology.
| Product Name: | Elk1 Transcription Factor Activity Assay |
| Product Code: | TFAB00096 |
| Target: | Elk1 |
| Reactivity: | Human, Mouse |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie Elk1 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | ELK1: a transcription factor of the Ets family and the ternary complex factor (TCF) subfamily. Forms a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. Mediates gene activity in response to serum and growth factors. Phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus; phosphorylation at these sites is critical for transcriptional activation by Elk-1. Two alternatively-spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: Xp11.2 Cellular Component: cell soma; dendrite; mitochondrion; nerve terminal; nucleoplasm; nucleus Molecular Function:chromatin binding; protein binding; transcription factor activity Biological Process: cell differentiation; innate immune response; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to light stimulus; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012] |
| UniProt Code: | P19419 |
| NCBI GenInfo Identifier: | 12643407 |
| NCBI Gene ID: | 2002 |
| NCBI Accession: | P19419.2 |
| UniProt Secondary Accession: | P19419,O75606, O95058, Q969X8, Q9UJM4, B2R7H4, |
| UniProt Related Accession: | P19419 |
| Molecular Weight: | |
| NCBI Full Name: | ETS domain-containing protein Elk-1 |
| NCBI Synonym Full Names: | ELK1, ETS transcription factor |
| NCBI Official Symbol: | ELK1 |
| NCBI Protein Information: | ETS domain-containing protein Elk-1 |
| UniProt Protein Name: | ETS domain-containing protein Elk-1 |
| Protein Family: | ETS domain-containing protein |
| UniProt Gene Name: | ELK1 |
| UniProt Entry Name: | ELK1_HUMAN |
