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Anti-ERCC1 Antibody (CAB4971)

SKU:
CAB4971
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
COFS4
RAD10
UV20
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 5 Anti-ERCC1 Antibody CAB4971
  • Epigenetics and Nuclear Signaling Antibodies 5 Anti-ERCC1 Antibody CAB4971
€139 - €419
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Description

Product Name:ERCC1 Rabbit mAb
Product Code:CAB4971
Size:20uL, 50uL, 100uL
Synonyms:COFS4, RAD10, UV20
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ERCC1
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, HepG2, SKOV3
Immunogen:A synthesized peptide derived from human ERCC1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2067
Uniprot:P07992
Calculated MW:36kDa
Observed MW:39KDa
UniProt Protein Function:Isoform 1: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.
NCBI Summary:The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]
UniProt Code:P07992
NCBI GenInfo Identifier:119538
NCBI Gene ID:2067
NCBI Accession:P07992.1
UniProt Secondary Accession:P07992,Q7Z7F5, Q96S40, B2RC01, B3KRR0,
UniProt Related Accession:P07992
Molecular Weight:25,211 Da
NCBI Full Name:DNA excision repair protein ERCC-1
NCBI Synonym Full Names:ERCC excision repair 1, endonuclease non-catalytic subunit
NCBI Official Symbol:ERCC1  
NCBI Official Synonym Symbols:UV20; COFS4; RAD10  
NCBI Protein Information:DNA excision repair protein ERCC-1
UniProt Protein Name:DNA excision repair protein ERCC-1
Protein Family:DNA excision repair protein
UniProt Gene Name:ERCC1  
UniProt Entry Name:ERCC1_HUMAN

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