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Anti-Erk1/2 Antibody

Datasheet
SKU STPA00016
Antibody Type Polyclonal
Applications WB
Applications IHC
Applications ICC/IF
Applications FCM
Reactivity Human
Reactivity Mouse
Reactivity Rat
Reactivity Bovine
Reactivity Sheep
Reactivity Chicken
Reactivity Fruit Fly (Drosophila melanogaster)
Reactivity African clawed frog (Xenopus laevis)
Host Species Rabbit
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Description

Erk1/2 Antibody

Erk1/2 Antibody is a rabbit polyclonal antibody directed against Erk1/2, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF and FCM. Reported reactivity: Human, Mouse, Rat, Bovine, Sheep, Chicken, Fruit Fly (Drosophila melanogaster) and African clawed frog (Xenopus laevis). Purified by Peptide Affinity.

Extracellular signal-regulated kinases 1 and 2 (Erk1/2) are central components of the MAPK signaling cascade, orchestrating cellular responses to growth factors, stress, and synaptic activity. In the nervous system, Erk1/2 regulate neuronal differentiation, synaptic plasticity, and memory formation. Dysregulation of Erk1/2 signaling has been implicated in the pathogenesis of multiple neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s disease. Aberrant Erk1/2 activation can lead to chronic neuroinflammation, oxidative stress, and tau hyperphosphorylation—hallmarks of neurodegeneration. Conversely, controlled Erk1/2 signaling supports neuroprotection, axonal regeneration, and cognitive resilience. This dual role positions Erk1/2 as both a biomarker and a therapeutic target in neurodegenerative research. As precision medicine advances, modulating Erk1/2 activity offers a promising strategy to restore neuronal function and delay disease progression. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µl. For research use only; not for diagnostic or therapeutic procedures.

Product Name:Erk1/2 Antibody
Product SKU:STPA00016
Size:100 µl
Target:Erk1/2
Host Species:Rabbit
Antibody Type:Polyclonal
Research Areas:Cell Signaling, Post-translational Modifications, Phosphorylation, Neuroscience, Neurodegeneration, Alzheimer's Disease
Buffer:PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:Liquid
Applications:WB, IHC, ICC/IF, FCM
Purification:Peptide Affinity Purified
Concentration:1 mg/ml
Reactivity:Human, Mouse, Rat, Bovine, Sheep, Chicken, Fruit Fly (Drosophila melanogaster), African clawed frog (Xenopus laevis)
Recommended Dilution:WB (1:1000), IHC (1:100), ICC/IF (1:100), FCM (1:100); optimal dilutions for assays should be determined by the user.
Specificity:Detects ~44kda (ERK1) and ~42kDa (ERK2).
Guarantee:12 months from date of dispatch
Immunogen:A 35 residue synthetic peptide, corresponding to Rat Erk1 MAP kinase with the CGG spacer group added and the peptide coupled to KLH.
Immunogen Species:Rat
Accession Number:NP_059043.1
Gene ID:50689
Swiss-Prot:P21708
Cellular Localization:Cytoplasm | Nucleus
Alternative Names:ERK1, ERK2, ERT1, ERT2, MAP kinase 1, MAP kinase 2, MAPK1, MAPK2, MAPK3, p38, p40, p41, p41mapk, p42 MAPK, p44 ERK1, p44 MAPK, PRKM1, PRKM2, PRKM3
References:1. Boulton TG. et al. (1991) Biochemistry. 30(1):278-86. 2. Yoon S., and Seger R. (2006) Growth Factors 24:21-44. 3. Wolf G. (2005) Antioxid Redox Signal 7:1337-1345. 4. Chuerland D., Marmor G., Shainskaya A. and Seger R. (2008) J Biol Chem. Epub: http://www.jbc.org/cgi/doi/10.1074/jbc.M709030200 5. Zhuang S., and Schnellmann R.G. (2006) J Pharmacol Exp Ther 319:991-997.
Note:For research use only.

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