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Anti-ERp57 Antibody (CAB4376)

SKU:
CAB4376
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ER60
ERp57
ERp60
ERp61
GRP57
GRP58
HEL-S-269
HEL-S-93n
HsT17083
P58
PI-PLC
Research Area:
Cell Biology
  • Cell Biology Antibodies 17 Anti-ERp57 Antibody CAB4376
  • Cell Biology Antibodies 17 Anti-ERp57 Antibody CAB4376
€139 - €419
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Description

Product Name:ERp57 Rabbit mAb
Product Code:CAB4376
Size:20uL, 50uL, 100uL
Synonyms:ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HEL-S-269, HEL-S-93n, HsT17083, P58, PI-PLC
Applications:WB, IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ERp57
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:293T, HepG2
Immunogen:A synthesized peptide derived from human ERp57
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2923
Uniprot:P30101
Cellular Location:Endoplasmic reticulum, Endoplasmic reticulum lumen, Melanosome
Calculated MW:57kDa
Observed MW:57KDa
UniProt Protein Function:GRP58: a protein disulfide isomerase found in the endoplasmic reticulum lumen. Catalyzes the rearrangement of both intrachain and interchain disulfide bonds in proteins to form the native structures. An essential component of the peptide-loading complex of the major histocompatibility complex class I pathway.
UniProt Protein Details:

Protein type:Chaperone; Endoplasmic reticulum; Protease; Isomerase; EC 5.3.4.1; Apoptosis; Phospholipase

Chromosomal Location of Human Ortholog: 15q15

Cellular Component: smooth endoplasmic reticulum; cell surface; focal adhesion; endoplasmic reticulum; endoplasmic reticulum lumen; melanosome; nucleus

Molecular Function:disulfide oxidoreductase activity; protein binding; cysteine-type endopeptidase activity; protein disulfide isomerase activity; phospholipase C activity

Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; protein folding; protein import into nucleus; cell redox homeostasis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein amino acid N-linked glycosylation via asparagine; signal transduction; proteolysis; post-translational protein modification; protein retention in ER

NCBI Summary:This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008]
UniProt Code:P30101
NCBI GenInfo Identifier:2507461
NCBI Gene ID:2923
NCBI Accession:P30101.4
UniProt Secondary Accession:P30101,Q13453, Q14255, Q8IYF8, Q9UMU7,
UniProt Related Accession:P30101,AAB37397
Molecular Weight:56,782 Da
NCBI Full Name:Protein disulfide-isomerase A3
NCBI Synonym Full Names:protein disulfide isomerase family A, member 3
NCBI Official Symbol:PDIA3  
NCBI Official Synonym Symbols:P58; ER60; ERp57; ERp60; ERp61; GRP57; GRP58; PI-PLC; HsT17083; HEL-S-269; HEL-S-93n  
NCBI Protein Information:protein disulfide-isomerase A3; ER protein 57; ER protein 60; phospholipase C-alpha; 58 kDa microsomal protein; disulfide isomerase ER-60; endoplasmic reticulum P58; 58 kDa glucose-regulated protein; glucose regulated protein, 58kDa; epididymis secretory protein Li 269; protein disulfide isomerase-associated 3; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 93n
UniProt Protein Name:Protein disulfide-isomerase A3
UniProt Synonym Protein Names:58 kDa glucose-regulated protein; 58 kDa microsomal protein; p58; Disulfide isomerase ER-60; Endoplasmic reticulum resident protein 57; ER protein 57; ERp57; Endoplasmic reticulum resident protein 60; ER protein 60; ERp60
Protein Family:Protein disulfide-isomerase
UniProt Gene Name:PDIA3  
UniProt Entry Name:PDIA3_HUMAN

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