ETV1 Rabbit Polyclonal Antibody (CAB13303)
- SKU:
- CAB13303
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | ETV1 Rabbit Polyclonal Antibody |
SKU: | CAB13303 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-300 of human ETV1 (NP_004947.2). |
Sequence: | AFHG LPLK IKKE PHSP CSEI SSAC SQEQ PFKF SYGE KCLY NVSA YDQK PQVG MRPS NPPT PSST PVSP LHHA SPNS THTP KPDR AFPA HLPP SQSI PDSS YPMD HRFR RQLS EPCN SFPP LPTM PREG RPMY QRQM SEPN IPFP PQGF KQEY HDPV YEHN TMVG SAAS QSFP PPLM IKQE PRDF AYDS EVPS CHSI YMRQ EGFL AHPS RTEG CMFE KGPR Q |
Tested Applications: | IHC-P IF/ICC ELISA |
Recommended Dilution: | IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | ER81; ETV1 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 55kDa |
This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method: | Affinity purification |
Gene ID: | 2115 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |