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Anti-FCGR2A Antibody (CAB1388)

SKU:
CAB1388
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 1 Anti-FCGR2A Antibody CAB1388
  • Immunology Antibodies 1 Anti-FCGR2A Antibody CAB1388
€139 - €419
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Description

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Antibody Name:Anti-FCGR2A Antibody
Antibody SKU:CAB1388
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 34-316 of human FCGR2A (NP_067674.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:K-562, Mouse spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 34-316 of human FCGR2A (NP_067674.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QAAP PKAV LKLE PPWI NVLQ EDSV TLTC QGAR SPES DSIQ WFHN GNLI PTHT QPSY RFKA NNND SGEY TCQT GQTS LSDP VHLT VLSE WLVL QTPH LEFQ EGET IMLR CHSW KDKP LVKV TFFQ NGKS QKFS HLDP TFSI PQAN HSHS GDYH CTGN IGYT LFSS KPVT ITVQ VPSM GSSS PMGI IVAV VIAT AVAA IVAA VVAL IYCR KKRI SANS TDPV KAAQ FEPP GRQM IAIR KRQL EETN NDYE TADG GYMT LNPR APTD DDKN IYLT LPPN DHVN SNN
Gene ID:2212
Uniprot:P12318
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:34kDa/35kDa
Observed MW:40-50KDa
Synonyms:FCGR2A, CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, IGFR2
Background:This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:FCGR2A: low affinity receptor for the Fc region of IgGs. Binding to IgG initiates cellular responses against pathogens and soluble antigens. A type I membrane protein found on monocytes, neutrophils and platelets. SHP-1 associates with this protein to modulate signaling events in myeloid cells.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.; Cell surface

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: plasma membrane

Molecular Function:protein binding

Disease: Malaria, Susceptibility To; Systemic Lupus Erythematosus

NCBI Summary:This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
UniProt Code:P12318
NCBI GenInfo Identifier:160332371
NCBI Gene ID:2212
NCBI Accession:P12318.4
UniProt Secondary Accession:P12318,Q8WUN1, Q8WW64,
UniProt Related Accession:P12318
Molecular Weight:34,930 Da
NCBI Full Name:Low affinity immunoglobulin gamma Fc region receptor II-a
NCBI Synonym Full Names:Fc fragment of IgG receptor IIa
NCBI Official Symbol:FCGR2A  
NCBI Official Synonym Symbols:CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1  
NCBI Protein Information:low affinity immunoglobulin gamma Fc region receptor II-a
UniProt Protein Name:Low affinity immunoglobulin gamma Fc region receptor II-a
UniProt Synonym Protein Names:CDw32; Fc-gamma RII-a; Fc-gamma-RIIa; FcRII-a; CD_antigen: CD32
Protein Family:Low affinity immunoglobulin gamma Fc region receptor
UniProt Gene Name:FCGR2A  
UniProt Entry Name:FCG2A_HUMAN
Anti-FCGR2A Antibody (CAB1388)Western blot analysis of extracts of various cell lines, using FCGR2A antibody (CAB1388) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-FCGR2A Antibody (CAB1388)Immunofluorescence analysis of mouse spleen using FCGR2A Rabbit pAb (CAB1388) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

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