Anti-FCGRT Antibody (CAB8544)

Antibody Name:	Anti-FCGRT Antibody
Antibody SKU:	CAB8544
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human FCGRT (NP_004098.1).

Application:	WB IF
Recommended Dilution:	WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	HL-60

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human FCGRT (NP_004098.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	ESHL SLLY HLTA VSSP APGT PAFW VSGW LGPQ QYLS YNSL RGEA EPCG AWVW ENQV SWYW EKET TDLR IKEK LFLE AFKA LGGK GPYT LQGL LGCE LGPD NTSV PTAK FALN GEEF MNFD LKQG TWGG DWPE ALAI SQRW QQQD KAAN KELT FLLF SCPH RLRE HLER GRGN LEWK EPPS MRLK ARPS SPGF SVLT CSAF SFYP PELQ LRFL RNGL AAGT GQGD FGPN SDGS FHAS SSLT VKSG DEHH YCCI VQHA GLAQ PLRV ELES PAKS SVLV
Gene ID:	2217
Uniprot:	P55899
Cellular Location:	Cell membrane, Single-pass type I membrane protein
Calculated MW:	39kDa
Observed MW:	40kDa

Synonyms:	FCGRT, FCRN, alpha-chain
Background:	This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	FCGRT: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus. Belongs to the immunoglobulin superfamily.
UniProt Protein Details:	Protein type:Immunoglobulin superfamily; Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: plasma membrane Molecular Function:antigen binding; beta-2-microglobulin binding; IgG binding; IgG receptor activity; peptide antigen binding Biological Process: antigen processing and presentation
NCBI Summary:	This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
UniProt Code:	P55899
NCBI GenInfo Identifier:	2497331
NCBI Gene ID:	2217
NCBI Accession:	P55899.1
UniProt Secondary Accession:	P55899,Q5HYM5, Q9HBV7, Q9NZ19,
UniProt Related Accession:	P55899
Molecular Weight:	39,743 Da
NCBI Full Name:	IgG receptor FcRn large subunit p51
NCBI Synonym Full Names:	Fc fragment of IgG receptor and transporter
NCBI Official Symbol:	FCGRT
NCBI Official Synonym Symbols:	FCRN; alpha-chain
NCBI Protein Information:	IgG receptor FcRn large subunit p51
UniProt Protein Name:	IgG receptor FcRn large subunit p51
UniProt Synonym Protein Names:	IgG Fc fragment receptor transporter alpha chain; Neonatal Fc receptor
Protein Family:	IgG receptor
UniProt Gene Name:	FCGRT
UniProt Entry Name:	FCGRN_HUMAN

	Western blot analysis of extracts of HL-60 cells, using FCGRT antibody (CAB8544) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
	Immunofluorescence analysis of C6 cells using FCGRT Rabbit pAb (CAB8544) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

ELISA Kits

Human IgG receptor FcRn large subunit p51 / FCGRT ELISA Kit

Human IgG receptor FcRn large subunit p51 (FCGRT) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)