Description

FITC Anti-Human CD74 Antibody [LN2]

The FITC Anti-Human CD74 Antibody (LN2) available at assaygenie.com is a crucial tool for researchers studying the CD74 protein in human samples. CD74 is a cell surface receptor involved in antigen presentation and immune responses. This highly specific antibody, raised against human samples, is validated for use in flow cytometry applications. It binds specifically to the CD74 protein, allowing for accurate detection and analysis in various cell types, making it an essential tool for immunology and cancer research.CD74, also known as the major histocompatibility complex (MHC) class II invariant chain, plays a vital role in the immune system by assisting in the presentation of antigens to T cells.

Understanding the functions and expression patterns of CD74 is crucial for unraveling its role in various diseases, including cancer, infectious diseases, and autoimmune disorders. Researchers exploring immune responses and antigen presentation mechanisms will benefit greatly from the reliable and validated FITC Anti-Human CD74 Antibody (LN2) offered by assaygenie.com.

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Product Title:	FITC Anti-Human CD74 Antibody [LN2]
SKU:	AGEL2167
Size:	20 Tests, 100 Tests, 200 Tests
Clone No:	LN2
Synonyms:	HLA class II histocompatibility antigen gamma chain;CD74;Ia antigen-associated invariant chain;Ii;p33;DHLAG;
Host Species:	Mouse
Reactivity:	Human
Application:	FCM

Isotype:	Mouse IgG1, κ
Isotype Control:	FITC Mouse IgG1, κ Isotype Control[MOPC-21]
Form:	Liquid
Conjugation:	FITC
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:

Swissprot:	P04233
Gene ID:	972
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.

FITC Anti-Human CD74 Antibody [LN2] (AGEL2167)

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