Description

Biotin Anti-Human CD74 Antibody [LN2]

The Human CD74 Monoclonal Antibody, Biotin Conjugated (LN2) is a powerful tool for researchers investigating the CD74 protein, a key player in immune responses and antigen presentation. This monoclonal antibody, conjugated with biotin, offers high specificity and sensitivity in detecting CD74 in human samples.CD74, also known as the major histocompatibility complex class II-associated invariant chain, is essential for the proper function of the immune system, playing a central role in antigen presentation and immune response regulation. By targeting CD74 with this antibody, researchers can effectively study its expression and localization in various cell types and tissues.

With its validation for use in applications such as immunohistochemistry and flow cytometry, the Human CD74 Monoclonal Antibody, Biotin Conjugated (LN2) is a valuable tool for studies in immunology, cancer research, and autoimmune disorders. By elucidating the role of CD74 in immune processes, researchers can gain insights that may lead to the development of novel therapeutic strategies targeting this protein.

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Product Title:	Biotin Anti-Human CD74 Antibody [LN2]
SKU:	AGEL0280
Size:	25µg, 100µg
Clone No:	LN2
Synonyms:	HLA class II histocompatibility antigen gamma chain;CD74;Ia antigen-associated invariant chain;Ii;p33;DHLAG;
Host Species:	Mouse
Reactivity:	Human
Application:	FCM

Isotype:	Mouse IgG1, κ
Isotype Control:	Biotin Mouse IgG1, κ Isotype Control[MOPC-21]
Form:	Liquid
Conjugation:	Biotin
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Swissprot:	P04233
Gene ID:	972
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.

Biotin Anti-Human CD74 Antibody [LN2] (AGEL0280)

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Description