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Purified Anti-Human CD74 Antibody [LN2] (AGEL0279)

Datasheet MSDS
SKU AGEL0279
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human
Host Species Mouse
Isotype IgG1
Clone LN2
Conjugation Unconjugated
Applications FC
$104 - $255

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Description

system_update_altDatasheetsystem_update_altMSDS

Purified Anti-Human CD74 Antibody [LN2]

The CD74 Monoclonal Antibody (LN2) is a specialized tool for researchers investigating the CD74 protein, a key regulator of antigen presentation and immune response modulation. This monoclonal antibody, known as AGEL0279, is specifically designed for human samples and has been rigorously validated for use in various applications, including immunohistochemistry and flow cytometry.CD74 is a crucial component of the MHC class II complex, playing a pivotal role in the immune response by facilitating antigen presentation to T cells and modulating immune pathways. The LN2 monoclonal antibody binds specifically to the CD74 protein, allowing researchers to visualize and analyze its expression in different cell types and tissue samples.

This makes it an invaluable tool for studies in immunology, oncology, and infectious diseases.Understanding the function and expression of CD74 is essential for unraveling its involvement in diseases such as cancer, autoimmune disorders, and infectious conditions. By utilizing the LN2 monoclonal antibody, researchers can delve deeper into the role of CD74 in these pathological processes, potentially leading to the development of targeted therapies and diagnostic tools.

Product Title:Purified Anti-Human CD74 Antibody [LN2]
SKU:AGEL0279
Size:25µg, 100µg
Clone No:LN2
Synonyms:HLA class II histocompatibility antigen gamma chain;CD74;Ia antigen-associated invariant chain;Ii;p33;DHLAG;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Purified Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P04233
Gene ID:972
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.
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