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FITC Anti-Mouse Foxp3 Antibody [3G3] (AGEL2482)

Datasheet MSDS
SKU AGEL2482
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications ICFCM
Reactivity Mouse
Host Species Mouse
Isotype Mouse IgG1, κ
Clone 3G3
Conjugation FITC
$238 - $565

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Description

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FITC Anti-Mouse Foxp3 Antibody [3G3]

The FITC Anti-Mouse Foxp3 Antibody (3G3) offered by Assay Genie is a vital tool for researchers investigating regulatory T cells and immune tolerance in mice. This antibody, raised against Foxp3, a key transcription factor for regulatory T cells, provides high specificity and sensitivity in flow cytometry and immunofluorescence applications. Its fluorescence properties allow for precise detection and quantification of Foxp3-expressing cells, enabling detailed analysis of immune responses and tolerance mechanisms in experimental models.Foxp3, a master regulator of regulatory T cells, plays a crucial role in maintaining immune homeostasis and preventing autoimmune reactions. Dysregulation of Foxp3 expression is associated with various autoimmune diseases and inflammatory conditions.

Therefore, studying Foxp3 expression and function is essential for understanding the mechanisms underlying immune tolerance and developing therapeutic strategies for immune-related disorders.With the FITC Anti-Mouse Foxp3 Antibody (3G3) from Assay Genie, researchers can delve deeper into the intricate mechanisms of immune regulation in mice, paving the way for advancements in immunotherapy, autoimmune disease research, and cancer immunology. Trust in the quality and reliability of this antibody to support your investigations into Foxp3 and regulatory T cell biology.

Product Title:FITC Anti-Mouse Foxp3 Antibody [3G3]
SKU:AGEL2482
Size:50 Tests, 100 Tests, 200 Tests
Clone No:3G3
Synonyms:Forkhead box protein P3;IPEX;JM2;Foxp3;
Host Species:Mouse
Reactivity:Mouse
Application:ICFCM
Isotype:Mouse IgG1, κ
Isotype Control:FITC Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q99JB6
Gene ID:50943,20371,317382
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2.
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