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PE Anti-Mouse Foxp3 Antibody [3G3] (AGEL2483)

Datasheet MSDS
SKU AGEL2483
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications ICFCM
Reactivity Mouse
Host Species Mouse
Isotype Mouse IgG1, κ
Clone 3G3
Conjugation PE
€180 - €428

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Description

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PE Anti-Mouse Foxp3 Antibody [3G3]

The PE Anti-Mouse Foxp3 Antibody (3G3) offered by Assay Genie is a valuable tool for research involving Foxp3, a key transcription factor involved in the development and function of regulatory T cells. This antibody, specific to mouse samples, is designed for flow cytometry applications and enables the detection and analysis of Foxp3-expressing cells in various experimental settings.Foxp3 is essential for the function of regulatory T cells, which play a crucial role in maintaining immune tolerance and preventing autoimmune responses. By targeting Foxp3, researchers can investigate the role of regulatory T cells in immune regulation, tolerance, and response to various stimuli.

This antibody facilitates the identification and characterization of Foxp3-expressing cells, providing insights into immune mechanisms and potential therapeutic targets for immune-related disorders.With its high specificity and sensitivity, the PE Anti-Mouse Foxp3 Antibody (3G3) is an essential tool for studies in immunology, autoimmune diseases, cancer immunotherapy, and transplantation research. Researchers can rely on this antibody to accurately assess Foxp3 expression in mouse samples, advancing our understanding of immune regulation and paving the way for the development of novel therapeutic strategies.

Product Title:PE Anti-Mouse Foxp3 Antibody [3G3]
SKU:AGEL2483
Size:50 Tests, 100 Tests, 200 Tests
Clone No:3G3
Synonyms:Forkhead box protein P3;IPEX;JM2;Foxp3;
Host Species:Mouse
Reactivity:Mouse
Application:ICFCM
Isotype:Mouse IgG1, κ
Isotype Control:PE Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q99JB6
Gene ID:50943,20371,317382
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2.
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