FKHRL1 (Phospho-Ser253) Transcription Factor Activity Assay

Product Name:	FKHRL1 (Phospho-Ser253) Transcription Factor Activity Assay
Product Code:	TFAB00028
Target:	FKHRL1 (Phospho-Ser253)
Synonyms:	AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1
Reactivity:	Human, Mouse
Sample Types:	Nuclear or cell lysates

The Assay Genie FKHRL1 (Phospho-Ser253) transcription factor activity assay allows for the detection and qualitative analysis of FKHRL1 (Phospho-Ser253) active transcription factors in eukaryotic nuclear or cell lysates.

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:	4.5 hours
Detection Method:	Colorimetric 450 nm
Size:	12 x 8-Well Microstrips
Storage:	4°C for 6 months

UniProt Protein Function:	FOXO3A: a transcription factors of the forkhead family. Contains 1 fork-head domain. May regulate apoptosis through control of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia.
UniProt Protein Details:	Protein type:Oncoprotein; DNA-binding; Transcription factor; Autophagy Chromosomal Location of Human Ortholog: 6q21 Cellular Component: nucleoplasm; membrane; cytoplasm; cytosol; nucleus Molecular Function:protein binding; DNA binding; chromatin DNA binding; sequence-specific DNA binding; transcription factor activity; protein kinase binding Biological Process: epidermal growth factor receptor signaling pathway; transcription from RNA polymerase II promoter; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; DNA damage response, signal transduction by p53 class mediator; nerve growth factor receptor signaling pathway; initiation of primordial ovarian follicle growth; positive regulation of transcription, DNA-dependent; antral ovarian follicle growth; positive regulation of erythrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; ovulation from ovarian follicle; oocyte maturation; regulation of translation; regulation of transcription from RNA polymerase II promoter; positive regulation of neuron apoptosis; innate immune response; positive regulation of transcription from RNA polymerase II promoter
NCBI Summary:	This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
UniProt Code:	O43524
NCBI GenInfo Identifier:	8134467
NCBI Gene ID:	2309
NCBI Accession:	O43524.1
UniProt Secondary Accession:	O43524,O15171, Q5T2I7, Q9BZ04, B4DVZ6, E1P5E6,
UniProt Related Accession:	O43524
Molecular Weight:
NCBI Full Name:	Forkhead box protein O3
NCBI Synonym Full Names:	forkhead box O3
NCBI Official Symbol:	FOXO3
NCBI Official Synonym Symbols:	FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
NCBI Protein Information:	forkhead box protein O3; forkhead box O3A; forkhead in rhabdomyosarcoma-like 1; forkhead homolog (rhabdomyosarcoma) like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
UniProt Protein Name:	Forkhead box protein O3
UniProt Synonym Protein Names:	AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1
Protein Family:	Forkhead box protein
UniProt Gene Name:	FOXO3
UniProt Entry Name:	FOXO3_HUMAN

Antibodies	ELISA Kits
Anti-FOXO3A Antibody (CAB9270)	Human FOXO3 (Forkhead Box Protein O3) ELISA Kit (HUES02194)
Anti-Phospho-FOXO3-S253 Antibody (CABP0684)	FKHRL1 Transcription Factor Activity Assay
Anti-Phospho-FOXO3-S294 pAb Antibody (CABP0856)
Anti-Phospho-FOXO3-S253 Antibody (CABP1131)
Phospho-FOXO3 (S253) Antibody (PACO02753)