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FOXP2 Rabbit Polyclonal Antibody (CAB5677)

SKU:
CAB5677
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:FOXP2 Rabbit Polyclonal Antibody
SKU:CAB5677
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 590-715 of human FOXP2 (NP_055306.1).
Sequence:GSPT LVKN IPTS LGYG AALN ASLQ AALA ESSL PLLS NPGL INNA SSGL LQAV HEDL NGSL DHID SNGN SSPG CSPQ PHIH SIHV KEEP VIAE DEDC PMSL VTTA NHSP ELED DREI EEEP LSED LE
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:SPCH1; CAGH44; TNRC10; FOXP2
Positive Sample:293T,A-549,SH-SY5Y,SGC-7901,Mouse lung,Mouse brain，Mouse stomach，Rat brain
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:80kDa
Observed MW:80kDa

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.

Purification Method:Affinity purification
Gene ID:93986
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using FOXP2 antibody (CAB5677) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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