FUNDC1 Antibody is a rabbit polyclonal antibody directed against FUNDC1, offered by Assay Genie for research applications. Reported applications include WB and IHC. Reported reactivity: Human, Mouse and Rat. Purified by Peptide Affinity.
FUNDC1 (FUN14 domain-containing protein 1) is a mitochondrial outer membrane protein that functions as a mitophagy receptor, playing a critical role in the selective clearance of damaged mitochondria. Mitophagy is essential for maintaining mitochondrial quality control, especially in neurons, which are highly dependent on mitochondrial integrity for energy production, calcium buffering, and synaptic function. Under stress conditions such as hypoxia or oxidative damage, FUNDC1 interacts with LC3 through its LC3-interacting region (LIR) motif, initiating the engulfment of dysfunctional mitochondria by autophagosomes. This process is tightly regulated by phosphorylation and dephosphorylation events that modulate FUNDC1’s activity and binding affinity. In neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and amyotrophic lateral sclerosis (ALS), impaired mitophagy contributes to the accumulation of defective mitochondria, increased oxidative stress, and neuronal death. Dysregulation of FUNDC1-mediated mitophagy has been linked to mitochondrial fragmentation, disrupted energy metabolism, and neuroinflammation—key features of neurodegenerative pathology. FUNDC1 also participates in mitochondrial dynamics by interacting with proteins involved in fission and fusion, further influencing neuronal survival and plasticity. Its role in maintaining mitochondrial homeostasis positions FUNDC1 as a promising biomarker and therapeutic target in neurodegeneration. Targeting FUNDC1 to enhance mitophagy may offer a novel strategy to restore mitochondrial function and slow the progression of neurodegenerative diseases. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
