Description

GenieFluor Violet 450 Anti-Human CD8a Antibody [OKT-8]

The GenieFluor Violet 450 Anti-Human CD8a Antibody (OKT-8) is a cutting-edge tool for researchers investigating the CD8a protein, a crucial cell surface marker involved in immune responses and cytotoxic T cell function. This highly specific antibody, optimized for human samples, has been rigorously validated for use in flow cytometry and immunofluorescence applications. By targeting the CD8a protein, this antibody enables precise detection and analysis of CD8a-expressing cells in diverse research settings, making it an indispensable asset for studies in immunology, oncology, and infectious diseases.

CD8a, a core component of the CD8 T cell co-receptor complex, plays a pivotal role in antigen recognition and immune response modulation. Understanding the expression and function of CD8a is essential for unraveling the complexities of adaptive immunity, viral infections, and cancer immunology. The GenieFluor Violet 450 Anti-Human CD8a Antibody (OKT-8) provides researchers with a robust tool to investigate the distribution and activation status of CD8a+ T cells, paving the way for advancements in immunotherapy, vaccine development, and autoimmune disease research.

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Product Title:	GenieFluor Violet 450 Anti-Human CD8a Antibody [OKT-8]
SKU:	AGEL2768
Size:	20 Tests, 100 Tests, 200 Tests
Clone No:	OKT-8
Synonyms:	T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:	Mouse
Reactivity:	Human
Application:	FCM

Isotype:	Mouse IgG2a, κ
Isotype Control:	Genie Fluor Violet 450 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:	Liquid
Conjugation:	Genie FluorViolet 450
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:

Swissprot:	P01732
Gene ID:	925
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.

GenieFluor Violet 450 Anti-Human CD8a Antibody [OKT-8] (AGEL2768)

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Description