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GLP1R Rabbit Polyclonal Antibody (CAB8547)

SKU:
CAB8547
Product Type:
Antibody
Applications:
WB
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 12 Anti-GLP1R Antibody CAB8547
  • Cell Biology Antibodies 12 Anti-GLP1R Antibody CAB8547
€139 - €419
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Description

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Product Name:GLP1R Rabbit Polyclonal Antibody
SKU:CAB8547
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human GLP1R (NP_002053.3).
Sequence:MAGA PGPL RLAL LLLG MVGR AGPR PQGA TVSL WETV QKWR EYRR QCQR SLTE DPPP ATDL FCNR TFDE YACW PDGE PGSF VNVS CPWY LPWA SSVP QGHV YRFC TAEG LWLQ KDNS SLPW RDLS ECEE SKRG ERSS PEEQ
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200
Synonyms:GLP-1; GLP-1R; GLP-1-R; GLP1R
Positive Sample:Mouse lung,Rat stomach,Rat lung
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Multi-pass membrane protein.
Calculated MW:53kDa
Observed MW:53kDa

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:2740
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using GLP1R antibody (CAB8547) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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