Anti-GluA4 Antibody (CAB4593)

SKU:
CAB4593
€129 - €349

Description

Technical Manual

Anti-GluA4 Antibody

Product Name:Anti-GluA4 Antibody
Product SKU:CAB4593
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]

Immunogen:A synthesized peptide derived from human GluA4
Sequence:

Email for sequence

Gene ID:2893
Swiss Prot:P48058
Synonyms:GLUR4; GLUR4C; GLURD; GluA4
Calculated MW:101kDa
Observed MW:101KDa
Reactivity:Mouse, Rat
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting 
Positive Samples:Mouse brain, Rat brain
Cellular Location:

Product Images

Anti-GluA4 Antibody (CAB4593)

Western blot - GluA4 Rabbit mAb (CAB4593)

Uniprot Information

UniProt Protein Function:GluR4: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) > glutamate > kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q22

Cellular Component: cell junction; cell soma; dendrite; plasma membrane; postsynaptic membrane; terminal button

Molecular Function:alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity

Biological Process: glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; synaptic transmission; transport

NCBI Summary:Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]
UniProt Code:P48058
NCBI GenInfo Identifier:218512059
NCBI Gene ID:2893
NCBI Accession:P48058.2
UniProt Secondary Accession:P48058,Q86XE8,
UniProt Related Accession:P48058
Molecular Weight:49,146 Da
NCBI Full Name:Glutamate receptor 4
NCBI Synonym Full Names:glutamate ionotropic receptor AMPA type subunit 4
NCBI Official Symbol:GRIA4 
NCBI Official Synonym Symbols:GLUR4; GLURD; GluA4; GLUR4C 
NCBI Protein Information:glutamate receptor 4
UniProt Protein Name:Glutamate receptor 4
UniProt Synonym Protein Names:AMPA-selective glutamate receptor 4; GluR-D; Glutamate receptor ionotropic, AMPA 4; GluA4
Protein Family:Glutamate receptor
UniProt Gene Name:GRIA4 
UniProt Entry Name:GRIA4_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
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