UniProt Protein Function: | GUCA2B: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. Belongs to the guanylin family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1p34-p33 Molecular Function:calcium sensitive guanylate cyclase activator activity |
NCBI Summary: | This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. [provided by RefSeq, Nov 2015] |
UniProt Code: | Q16661 |
NCBI GenInfo Identifier: | 2495130 |
NCBI Gene ID: | 2981 |
NCBI Accession: | Q16661.1 |
UniProt Secondary Accession: | Q16661,Q52LV0, |
UniProt Related Accession: | Q16661 |
Molecular Weight: | 12,069 Da |
NCBI Full Name: | Guanylate cyclase activator 2B |
NCBI Synonym Full Names: | guanylate cyclase activator 2B |
NCBI Official Symbol: | GUCA2BÂ Â |
NCBI Official Synonym Symbols: | UGN; GCAP-IIÂ Â |
NCBI Protein Information: | guanylate cyclase activator 2B |
UniProt Protein Name: | Guanylate cyclase activator 2B |
UniProt Synonym Protein Names: | Guanylate cyclase C-activating peptide 2Alternative name(s):Guanylate cyclase C-activating peptide II; GCAP-II |
Protein Family: | Guanylate cyclase activator |
UniProt Gene Name: | GUCA2BÂ Â |
UniProt Entry Name: | GUC2B_HUMAN |